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Title: The interaction effect of parental rejection and oxytocin receptor gene polymorphism on depression: a cross-cultural study in non-clinical samples
Authors: Senese, Vincenzo Paolo
Shinohara, Kazuyuki
Venuti, Paola
Bornstein, Marc H.
Rosanio, Vittorio
Nasti, Carla
Neoh, Michelle Jin-Yee
Maresca, Marzia
Esposito, Gianluca
Keywords: Social sciences::Psychology
Issue Date: 2022
Source: Senese, V. P., Shinohara, K., Venuti, P., Bornstein, M. H., Rosanio, V., Nasti, C., Neoh, M. J., Maresca, M. & Esposito, G. (2022). The interaction effect of parental rejection and oxytocin receptor gene polymorphism on depression: a cross-cultural study in non-clinical samples. International Journal of Environmental Research and Public Health, 19(9), 5566-.
Journal: International Journal of Environmental Research and Public Health 
Abstract: Parental rejection has been consistently empirically implicated in a wide array of developmental, behavioural and psychological problems worldwide. However, the interaction effect between parental rejection in childhood and the oxytocin receptor genotype on psychological adjustment has yet to be investigated. The present study aimed to investigate gene-environment interaction effects between parental rejection (maternal and paternal) and oxytocin receptor (OXTR) gene polymorphisms (rs53576 and rs2254298) on depressive symptoms in adults in different cultural contexts. Adults from Italy and Japan (N = 133, age = 18-27 years, females = 68) were preliminarily genotyped and then completed the Parental Acceptance-Rejection Questionnaire for mothers and fathers and the Beck Depression Inventory. Hierarchical multiple regression analysis showed that paternal rejection was related to self-reported depression and that the effect of parental rejection was moderated by OXTR gene polymorphisms and nationality. Among Italians, OXTR rs2254298 A-carriers showed resilience to negative early parental care, whereas among Japanese, OXTR rs53576 non-A-carriers showed resistance to negative early paternal care. These findings align with expected relations between perceived acceptance-rejection and an individual's psychological adjustment, as proposed by interpersonal acceptance-rejection theory, and indicate the need for future studies adopting a multicultural and multilevel approach to better understand how the effects of parental rejection extend into adulthood.
ISSN: 1661-7827
DOI: 10.3390/ijerph19095566
Schools: School of Social Sciences 
Rights: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
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