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Title: Age-related eye diseases in individuals with mild cognitive impairment and Alzheimer's disease
Authors: Chua, Jacqueline
Zhang, Zheting
Wong, Damon
Tan, Bingyao
Kulantayan, Bhavani
Sng, Chelvin C. A.
Hilal, Saima
Venketasubramanian, Narayanaswamy
Tan, Boon Yeow
Cheung, Carol Y.
Garhöfer, Gerhard
Popa-Cherecheanu, Alina
Wong, Tien Yin
Chen, Christopher Li-Hsian
Schmetterer, Leopold
Keywords: Science::Medicine
Issue Date: 2022
Source: Chua, J., Zhang, Z., Wong, D., Tan, B., Kulantayan, B., Sng, C. C. A., Hilal, S., Venketasubramanian, N., Tan, B. Y., Cheung, C. Y., Garhöfer, G., Popa-Cherecheanu, A., Wong, T. Y., Chen, C. L. & Schmetterer, L. (2022). Age-related eye diseases in individuals with mild cognitive impairment and Alzheimer's disease. Frontiers in Aging Neuroscience, 14, 933853-.
Project: CG/C010A/2017_SERI 
Journal: Frontiers in Aging Neuroscience
Abstract: Introduction: Alzheimer’s disease (AD) and age-related eye diseases pose an increasing burden as the world’s population ages. However, there is limited understanding on the association of AD/cognitive impairment, no dementia (CIND) with age-related eye diseases. Methods: In this cross-sectional, memory clinic-based study of multiethnic Asians aged 50 and above, participants were diagnosed as AD (n = 216), cognitive impairment, no dementia (CIND) (n = 252), and no cognitive impairment (NCI) (n = 124) according to internationally accepted criteria. Retinal photographs were graded for the presence of age-related macular degeneration (AMD) and diabetic retinopathy (DR) using standard grading systems. Multivariable-adjusted logistic regression models were used to determine the associations between neurological diagnosis and odds of having eye diseases. Results: Over half of the adults had at least one eye disease, with AMD being the most common (60.1%; n = 356), followed by DR (8.4%; n = 50). After controlling for age, sex, race, educational level, and marital status, persons with AD were more likely to have moderate DR or worse (OR = 2.95, 95% CI = 1.15–7.60) compared with NCI. In the fully adjusted model, the neurological diagnosis was not associated with AMD (OR = 0.75, 95% CI = 0.45–1.24). Conclusion: Patients with AD have an increased odds of having moderate DR or worse, which suggests that these vulnerable individuals may benefit from specific social support and screening for eye diseases.
ISSN: 1663-4365
DOI: 10.3389/fnagi.2022.933853
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
School of Chemical and Biomedical Engineering 
Organisations: Singapore National Eye Centre
Singapore Eye Research Institute
Duke-NUS Medical School
Research Centres: SERI-NTU Advanced Ocular Engineering (STANCE)
Rights: © 2022 Chua, Zhang, Wong, Tan, Kulantayan, Sng, Hilal, Venketasubramanian, Tan, Cheung, Garhöfer, Popa-Cherecheanu, Wong, Chen and Schmetterer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SCBE Journal Articles

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