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Title: Molecular and nanoengineering approaches towards activatable cancer immunotherapy
Authors: Zhang, Chi
Pu, Kanyi
Keywords: Engineering::Chemical engineering
Issue Date: 2020
Source: Zhang, C. & Pu, K. (2020). Molecular and nanoengineering approaches towards activatable cancer immunotherapy. Chemical Society Reviews, 49(13), 4234-4253.
Project: M4081627.120
Journal: Chemical Society Reviews
Abstract: Cancer immunotherapy is an emerging treatment strategy that modulates the immune system to fight against cancer. Although several immunotherapeutic agents have been utilized in the clinic for cancer treatment, low patient response rates and potential immune-related adverse events remain two major challenges. With the merits of delivery controllability and modular flexibility, nanomedicines provide opportunities to facilitate immunotherapies for clinical translation in a safe and effective manner. In this review, we discuss the convergence of nanomedicine with immunotherapy with a focus on molecular and nanoengineering approaches towards activatable cancer immunotherapy. These activatable nanoagents exert immunotherapeutic action only in response to internal or external stimuli. This allows them to locally reprogram the tumor microenvironment and activate antitumor immunity while reducing the incidence of immune-related adverse events. The category of activatable immunotherapeutic nanoagents are discussed along with an overview of their clinical translation prospects and challenges.
ISSN: 0306-0012
DOI: 10.1039/c9cs00773c
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2020 The Royal Society of Chemistry. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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