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Title: Decoding task specific and task general functional architectures of the brain
Authors: Gupta, Sukrit
Lim, Marcus
Rajapakse, Jagath Chandana
Keywords: Engineering::Computer science and engineering
Issue Date: 2022
Source: Gupta, S., Lim, M. & Rajapakse, J. C. (2022). Decoding task specific and task general functional architectures of the brain. Human Brain Mapping, 43(9), 2801-2816.
Project: 2EP20121-0003
Journal: Human Brain Mapping
Abstract: Functional magnetic resonance imaging (fMRI) is used to capture complex and dynamic interactions between brain regions while performing tasks. Task related alterations in the brain have been classified as task specific and task general, depending on whether they are particular to a task or common across multiple tasks. Using recent attempts in interpreting deep learning models, we propose an approach to determine both task specific and task general architectures of the functional brain. We demonstrate our methods with a reference-based decoder on deep learning classifiers trained on 12,500 rest and task fMRI samples from the Human Connectome Project (HCP). The decoded task general and task specific motor and language architectures were validated with findings from previous studies. We found that unlike intersubject variability that is characteristic of functional pathology of neurological diseases, a small set of connections are sufficient to delineate the rest and task states. The nodes and connections in the task general architecture could serve as potential disease biomarkers as alterations in task general brain modulations are known to be implicated in several neuropsychiatric disorders.
ISSN: 1065-9471
DOI: 10.1002/hbm.25817
Schools: School of Computer Science and Engineering 
Rights: © 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCSE Journal Articles

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