Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/161630
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dc.contributor.authorCao, Changyuen_US
dc.contributor.authorYang, Nanen_US
dc.contributor.authorSu, Yanen_US
dc.contributor.authorZhang, Zheyeen_US
dc.contributor.authorWang, Chenxien_US
dc.contributor.authorSong, Xuejiaoen_US
dc.contributor.authorChen, Pengen_US
dc.contributor.authorWang, Wenjunen_US
dc.contributor.authorDong, Xiaochenen_US
dc.date.accessioned2022-09-12T08:43:26Z-
dc.date.available2022-09-12T08:43:26Z-
dc.date.issued2022-
dc.identifier.citationCao, C., Yang, N., Su, Y., Zhang, Z., Wang, C., Song, X., Chen, P., Wang, W. & Dong, X. (2022). Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme. Advanced Materials, 34(29), e2203236-. https://dx.doi.org/10.1002/adma.202203236en_US
dc.identifier.issn0935-9648en_US
dc.identifier.urihttps://hdl.handle.net/10356/161630-
dc.description.abstractNanozymes, which are inorganic nanomaterials mimicking natural enzyme activities, are bringing enormous opportunities to theranostics. Herein, a cytochrome c oxidase-like nanozyme (copper-silver alloy nanoparticle, Cu-Ag NP) is demonstrated for nanocatalytic cancer therapy. Loaded with bioreductive predrug (AQ4N), this Cu-Ag nanozyme unprecedentedly enables simultaneous starvation, ferroptosis, and chemical therapy with high specificity, and is able to totally eliminate tumor and greatly prolong the survival rate for 4T1-tumor-bearing mice. The underlying working mechanism is revealed both experimentally and theoretically.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relationMOE2019-T2-2-004en_US
dc.relation.ispartofAdvanced Materialsen_US
dc.rights© 2022 Wiley-VCH GmbH. All rights reserved. This is the peer reviewed version of the following article: Cao, C., Yang, N., Su, Y., Zhang, Z., Wang, C., Song, X., Chen, P., Wang, W. & Dong, X. (2022). Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme. Advanced Materials, 34(29), e2203236-. https://dx.doi.org/10.1002/adma.202203236, which has been published in final form at https://dx.doi.org/10.1002/adma.202203236. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectEngineering::Chemical engineeringen_US
dc.subjectScience::Medicineen_US
dc.titleStarvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozymeen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1002/adma.202203236-
dc.description.versionSubmitted/Accepted versionen_US
dc.identifier.pmid35562328-
dc.identifier.scopus2-s2.0-85131239747-
dc.identifier.issue29en_US
dc.identifier.volume34en_US
dc.identifier.spagee2203236en_US
dc.subject.keywordsFerroptosisen_US
dc.subject.keywordsNanozymeen_US
dc.description.acknowledgementThe work was supported by NNSF of China (62120106002, 22175089, 61935004), Jiangsu Province Policy Guidance Plan (BZ2019014), Jiangsu Provincial key research and development plan (BE2021711), NSF of Ningbo (202003N40448), NSF of Shandong Province (ZR2020KB018), “Taishan scholars” construction special fund of Shandong Province, and AcRF Tier-2 grant (MOE2019-T2-2-004) from Ministry of Education of Singapore.en_US
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