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Title: Multienzyme nanoassemblies: from rational design to biomedical applications
Authors: Li, Di
Xiong, Qirong
Liang, Li
Duan, Hongwei
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: Li, D., Xiong, Q., Liang, L. & Duan, H. (2021). Multienzyme nanoassemblies: from rational design to biomedical applications. Biomaterials Science, 9(22), 7323-7342.
Project: MOE2018-T2-2-128 
Journal: Biomaterials Science 
Abstract: Multienzyme nanoassemblies (MENAs) that combine the functions of several enzymes into one entity have attracted widespread research interest due to their improved enzymatic performance and great potential for multiple applications. Considerable progress has been made to design and fabricate MENAs in recent years. This review begins with an introduction of the up-to-date strategies in designing MENAs, mainly including substrate channeling, compartmentalization and control of enzyme stoichiometry. The desirable properties that endow MENAs with important applications are also discussed in detail. Then, the recent advances in utilizing MENAs in the biomedical field are reviewed, with a particular focus on biosensing, tumor therapy, antioxidant and drug delivery. Finally, the challenges and perspectives for development of versatile MENAs are summarized.
ISSN: 2047-4830
DOI: 10.1039/d1bm01106e
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2021 The Royal Society of Chemistry. All rights reserved. This paper was published in Biomaterials Science and is made available with permission of The Royal Society of Chemistry.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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