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Title: a comparative transcriptomics database for protists
Authors: Villanueva, Erielle Marie Fajardo
Lim, Peng Ken
Lim, Jolyn Jia Jia
Lim, Shan Chun
Lau, Pei Yi
Koh, Kenny Ting Sween
Tan, Emmanuel
Kairon, Ryanjit Singh
See, Wei An
Liao, Jian Xiang
Hee, Ker Min
Vijay, Varsheni
Maitra, Ishani
Boon, Chong Jun
Fo, Kevin
Wang, Yee Tat
Jaya, Ryan
Hew, Anne Li
Lim, Yong Yee
Lee, Wei Quan
Lee, Zhi Qi
Foo, Herman
dos Santos, Adriana Lopes
Mutwil, Marek
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Villanueva, E. M. F., Lim, P. K., Lim, J. J. J., Lim, S. C., Lau, P. Y., Koh, K. T. S., Tan, E., Kairon, R. S., See, W. A., Liao, J. X., Hee, K. M., Vijay, V., Maitra, I., Boon, C. J., Fo, K., Wang, Y. T., Jaya, R., Hew, A. L., Lim, Y. Y., ...Mutwil, M. (2022). a comparative transcriptomics database for protists. Journal of Molecular Biology, 434(11), 167502-.
Journal: Journal of Molecular Biology 
Abstract: During the last few decades, the study of microbial ecology has been enabled by molecular and genomic data. DNA sequencing has revealed the surprising extent of microbial diversity and how microbial processes run global ecosystems. However, significant gaps in our understanding of the microbial world remain, and one example is that microbial eukaryotes, or protists, are still largely neglected. To address this gap, we used gene expression data from 17 protist species to create an online database equipped with tools for identifying co-expressed genes, gene families, and co-expression clusters enriched for specific biological functions. Here, we show how our database can be used to reveal genes involved in essential pathways, such as the synthesis of secondary carotenoids in Haematococcus lacustris. We expect to serve as a valuable resource for protistologists, as well as a catalyst for discoveries and new insights into the biological processes of microbial eukaryotes. AVAILABILITY: The database and co-expression networks are freely available from The expression matrices and sample annotations are found in the supplementary data.
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2022.167502
Schools: School of Biological Sciences 
Asian School of the Environment 
Rights: © 2022 Elsevier Ltd. All rights reserved. This paper was published in Journal of Molecular Biology and is made available with permission of Elsevier Ltd.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:ASE Journal Articles
SBS Journal Articles

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