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Title: Elucidating membrane proteomic responses of Escherichia coli to alcohol stress
Authors: Sen, Oishi
Keywords: Science::Biological sciences
Issue Date: 2022
Publisher: Nanyang Technological University
Source: Sen, O. (2022). Elucidating membrane proteomic responses of Escherichia coli to alcohol stress. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Bioalcohol is a renewable and environment-friendly alternative to present day fossil fuels, which are non-renewable and greenhouse gas emitters. However, alcohol toxicity to microbial cells is the limiting factor to profitable, large-scale production of alcohol by fermentation. An in-depth understanding of how the bacterial cells respond to alcohol stress by altering its membrane proteome can provide valuable information, which might be useful in improving microbial tolerance to alcohol and hence enable large scale production. The current study deals with the understanding of changes in the membrane protein composition of Escherichia coli in the presence of ethanol, butanol and hexanol. Further, the study focusses on confirming the changes in the expression of important outer membrane proteins under alcohol stress and predict the effect of such response on the functional integrity of the outer membrane.
DOI: 10.32657/10356/161698
Schools: School of Biological Sciences 
Research Centres: Singapore Centre for Environmental Life Sciences and Engineering (SCELSE) 
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: embargo_20240915
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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