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Title: Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss
Authors: Kallab, Martin
Hommer, Nikolaus
Schlatter, Andreas
Chua, Jacqueline
Tan, Bingyao
Schmidl, Doreen
Hirn, Cornelia
Findl, Oliver
Schmetterer, Leopold
Garhöfer, Gerhard
Wong, Damon
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Kallab, M., Hommer, N., Schlatter, A., Chua, J., Tan, B., Schmidl, D., Hirn, C., Findl, O., Schmetterer, L., Garhöfer, G. & Wong, D. (2022). Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss. Annals of the New York Academy of Sciences, 1511(1), 133-141.
Project: TA/MOH-000249-00/2018 
Journal: Annals of the New York Academy of Sciences 
Abstract: We compare the focal structure-function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL-T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT-angiography (OCT-A), or a combination of both, with visual field deviation (VFD) in early to advanced glaucoma. Primary open angle glaucoma patients (n = 46, mean ± SD age: 67 ± 10 years; VF mean deviation: -10.41 ± 6.76 dB) were included in this cross-sectional study. We performed 30-2 standard automated perimetry OCT (3.5-mm diameter ring scan) and 15°×15° OCT-A (superficial vascular complex slab). Based on a nerve fiber trajectory model, each VF test spot was assigned to an OCT-A wedge and an OCT ring-sector. Two univariate linear models (Mv and Mt ) using either CD-based vascular (Mv ) or RNFL-T-based thickness information (Mt ) and one multivariate model using both (Mv:t ) were compared in their associations with measured focal VFD, which were higher for the multivariate model Mv:t (mean ± SD correlation coefficient: 0.710 ± 0.086) than for either nested model (0.627 ± 0.078 for Mv and 0.578 ± 0.095 for Mt ). Using a focal visual field approach, the combination of RNFL-T and CD showed better structure-function correlations than thickness or vascular information only.
ISSN: 0077-8923
DOI: 10.1111/nyas.14732
Schools: School of Chemical and Biomedical Engineering 
Organisations: Singapore National Eye Centre 
Duke-NUS Medical School 
Research Centres: SERI-NTU Advanced Ocular Engineering (STANCE)
Rights: © 2022 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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