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|Title:||Disruption of dual homeostasis by a metal-organic framework nanoreactor for ferroptosis-based immunotherapy of tumor||Authors:||Zhang, Kai
|Keywords:||Science::Chemistry::Biochemistry||Issue Date:||2022||Source:||Zhang, K., Ma, Z., Li, S., Wu, Y., Zhang, J., Zhang, W., Zhao, Y. & Han, H. (2022). Disruption of dual homeostasis by a metal-organic framework nanoreactor for ferroptosis-based immunotherapy of tumor. Biomaterials, 284, 121502-. https://dx.doi.org/10.1016/j.biomaterials.2022.121502||Journal:||Biomaterials||Abstract:||Ferroptosis, a newfound non-apoptotic cell death pathway that is iron- and reactive oxygen species (ROS)-dependent, has shown a promise for tumor treatment. However, engineering ferroptosis inducers with sufficient hydrogen peroxide (H2O2) and iron supplying capacity remains a great challenge. To address this issue, herein, we report a powerful nanoreactor by modifying MnO2, glucose oxidase, and polyethylene glycol on iron-based metal-organic framework nanoparticles for disrupting redox and iron metabolism homeostasis, directly providing the Fenton reaction-independent downstream ferroptosis for tumor therapy. By consuming glutathione and oxidizing glucose to increase the H2O2 level in cancer cells and downregulating ferroportin 1 to accumulate intracellular iron ions, the homeostasis disruptor could effectively enhance the ferroptosis. Subsequently, the ferroptosis cells release tumor immune-associated antigens, which combine with in situ injected aptamer-PD-L1 to further strengthen the tumor treatment efficiency. This work not only paves a way to enhance the efﬁcacy of ferroptosis-based cancer therapy by associating intracellular redox homeostasis with the iron metabolism system in tumor cells but also offers an engineered nanoreactor as a promising mimetic antigen for activating immunotherapy.||URI:||https://hdl.handle.net/10356/161844||ISSN:||0142-9612||DOI:||10.1016/j.biomaterials.2022.121502||Schools:||School of Physical and Mathematical Sciences||Rights:||© 2022 Elsevier Ltd. All rights reserved.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
Updated on Nov 25, 2023
Updated on Nov 25, 2023
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