Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/161920
Title: Comparing environmental impacts of direct compaction versus wet granulation tableting methods for drugs with poor flowability by life cycle assessment
Authors: Hadinoto, Kunn
Tran, The-Thien
Chua, Angeline
Cheow, Wean Sin
Keywords: Engineering::Chemical engineering
Issue Date: 2022
Source: Hadinoto, K., Tran, T., Chua, A. & Cheow, W. S. (2022). Comparing environmental impacts of direct compaction versus wet granulation tableting methods for drugs with poor flowability by life cycle assessment. Chemical Engineering Research and Design, 183, 439-451. https://dx.doi.org/10.1016/j.cherd.2022.05.029
Journal: Chemical Engineering Research and Design
Abstract: Pharmaceutical tablet productions by direct compaction (DC) are more environmentally sustainable than wet granulation (WG) owed to DC's lower energy consumption. For drug particles with poor flowability, however, the environmental benefits of DC become questionable because DC of such drugs requires either pre-compaction treatment, increased excipients’ proportion in the tablets, or using excipients with unfavorable sustainability profiles. Using ibuprofen (IBU) as the model drug with poor flowability, we performed cradle-to-gate life cycle assessment (LCA) using ReCiPe 2016 method to characterize the environmental impacts of DC and WG tablet productions. Material and energy flow data from laboratory-scale (1 and 2.2 kg IBU) and simulated pilot-scale (25 kg IBU) productions were utilized in the LCA. Despite the increased proportion of excipients with less-than-ideal sustainability profile in DC tablets, the environmental impacts of DC tablet production remained smaller than WG tablet production across different production scales, as the impacts were governed by process-level energy consumption. The impacts of DC and WG tablet productions, nevertheless, became closer in magnitude with increasing production scale attributed to superior improvements in the energy requirement and yield of WG tablets. Thus, the environmental beneftis of DC tablets over WG tablets was diminished for drugs with poor flowability.
URI: https://hdl.handle.net/10356/161920
ISSN: 0263-8762
DOI: 10.1016/j.cherd.2022.05.029
Rights: © 2022 Institution of Chemical Engineers. Published by Elsevier Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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