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dc.contributor.authorDeng, Jingyuen_US
dc.contributor.authorMohammed Shahrudin Ibrahimen_US
dc.contributor.authorTan, Li Yangen_US
dc.contributor.authorYeo, Xin Yien_US
dc.contributor.authorLee, Yong Anen_US
dc.contributor.authorPark, Sung Jinen_US
dc.contributor.authorWüstefeld, Torstenen_US
dc.contributor.authorPark, June-Wooen_US
dc.contributor.authorJung, Sangyongen_US
dc.contributor.authorCho, Nam-Joonen_US
dc.identifier.citationDeng, J., Mohammed Shahrudin Ibrahim, Tan, L. Y., Yeo, X. Y., Lee, Y. A., Park, S. J., Wüstefeld, T., Park, J., Jung, S. & Cho, N. (2022). Microplastics released from food containers can suppress lysosomal activity in mouse macrophages. Journal of Hazardous Materials, 435, 128980-.
dc.description.abstractThe ingestion and accumulation of microplastics is a serious threat to the health and survival of humans and other organisms given the increasing use of daily-use plastic products, especially during the COVID-19 pandemic. However, whether direct microplastic contamination from plastic packaging is a threat to human health remains unclear. We analyzed the market demand for plastic packaging in Asia-Pacific, North America, and Europe and identified the commonly used plastic food packaging products. We found that food containers exposed to high-temperature released more than 10 million microplastics per mL in water. Recycled plastic food packaging was demonstrated to continuously leach micro- and nanoplastics. In vitro cell engulfing experiments revealed that both micro- and nanoplastic leachates are readily taken up by murine macrophages without any preconditioning, and that short-term microplastic exposure may induce inflammation while exposure to nanoplastic substantially suppressed the lysosomal activities of macrophages. We demonstrated that the ingestion of micro- and nanoplastics released from food containers can exert differential negative effects on macrophage activities, proving that the explosive growth in the use of plastic packaging can poses significant health risks to consumers.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.relation.ispartofJournal of Hazardous Materialsen_US
dc.rights© 2022 Published by Elsevier B.V. All rights reserved.en_US
dc.titleMicroplastics released from food containers can suppress lysosomal activity in mouse macrophagesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.subject.keywordsPlastic Food Packagesen_US
dc.description.acknowledgementThis work was supported by the AcRF Tier 1 granted by Ministry of Education (MOE), Singapore (grant numbers TIER1-2020-T1-002-032). This work was also supported by the China-Singapore International Joint Research Institute (CSIJRI). Besides, this work was also supported by A*STAR - Joint Council Project Grants, Singapore (Grant No. BMSI/15-800003-SBIC-OOE).en_US
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