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Title: Microplastics released from food containers can suppress lysosomal activity in mouse macrophages
Authors: Deng, Jingyu
Mohammed Shahrudin Ibrahim
Tan, Li Yang
Yeo, Xin Yi
Lee, Yong An
Park, Sung Jin
Wüstefeld, Torsten
Park, June-Woo
Jung, Sangyong
Cho, Nam-Joon
Keywords: Engineering::Materials
Issue Date: 2022
Source: Deng, J., Mohammed Shahrudin Ibrahim, Tan, L. Y., Yeo, X. Y., Lee, Y. A., Park, S. J., Wüstefeld, T., Park, J., Jung, S. & Cho, N. (2022). Microplastics released from food containers can suppress lysosomal activity in mouse macrophages. Journal of Hazardous Materials, 435, 128980-.
Project: TIER1-2020-T1-002-032
Journal: Journal of Hazardous Materials 
Abstract: The ingestion and accumulation of microplastics is a serious threat to the health and survival of humans and other organisms given the increasing use of daily-use plastic products, especially during the COVID-19 pandemic. However, whether direct microplastic contamination from plastic packaging is a threat to human health remains unclear. We analyzed the market demand for plastic packaging in Asia-Pacific, North America, and Europe and identified the commonly used plastic food packaging products. We found that food containers exposed to high-temperature released more than 10 million microplastics per mL in water. Recycled plastic food packaging was demonstrated to continuously leach micro- and nanoplastics. In vitro cell engulfing experiments revealed that both micro- and nanoplastic leachates are readily taken up by murine macrophages without any preconditioning, and that short-term microplastic exposure may induce inflammation while exposure to nanoplastic substantially suppressed the lysosomal activities of macrophages. We demonstrated that the ingestion of micro- and nanoplastics released from food containers can exert differential negative effects on macrophage activities, proving that the explosive growth in the use of plastic packaging can poses significant health risks to consumers.
ISSN: 0304-3894
DOI: 10.1016/j.jhazmat.2022.128980
Rights: © 2022 Published by Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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