Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162005
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dc.contributor.authorSung, Joseph Jao Yiuen_US
dc.contributor.authorWong, Sunny Heien_US
dc.date.accessioned2022-09-29T02:37:08Z-
dc.date.available2022-09-29T02:37:08Z-
dc.date.issued2022-
dc.identifier.citationSung, J. J. Y. & Wong, S. H. (2022). What is unknown in using microbiota as a therapeutic?. Journal of Gastroenterology and Hepatology, 37(1), 39-44. https://dx.doi.org/10.1111/jgh.15716en_US
dc.identifier.issn0815-9319en_US
dc.identifier.urihttps://hdl.handle.net/10356/162005-
dc.description.abstractFecal microbiota transplantation (FMT) has been used extensively in the treatment of various gastrointestinal and extraintestinal conditions, despite that there are still a lot of missing gaps in our knowledge in the gut microbiota and its behavior. This article describes the unknowns in microbiota biology (undetected microbes, uncertain colonization, unclear mechanisms of action, uncertain indications, unsure long-term efficacy, or side effects). We discuss how these unknowns may affect the therapeutic uses of FMT, and the potentials and caveats of other related microbiota-based therapies. When used as an experimental therapy or last resort in difficult conditions, caution should be taken against inadvertent complications. Clear documentations of post-treatment events should be made mandatory, classified, and graded as in clinical trials. Further robust scientific experiments and properly designed clinical studies are needed.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_US
dc.rights© 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. All rights reserved.en_US
dc.subjectScience::Medicineen_US
dc.titleWhat is unknown in using microbiota as a therapeutic?en_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1111/jgh.15716-
dc.identifier.pmid34668228-
dc.identifier.scopus2-s2.0-85118334046-
dc.identifier.issue1en_US
dc.identifier.volume37en_US
dc.identifier.spage39en_US
dc.identifier.epage44en_US
dc.subject.keywordsFecal Microbiota Transplantationen_US
dc.subject.keywordsMicrobiome Therapeuticsen_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
Appears in Collections:LKCMedicine Journal Articles

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