Please use this identifier to cite or link to this item:
Title: What is unknown in using microbiota as a therapeutic?
Authors: Sung, Joseph Jao Yiu
Wong, Sunny Hei
Keywords: Science::Medicine
Issue Date: 2022
Source: Sung, J. J. Y. & Wong, S. H. (2022). What is unknown in using microbiota as a therapeutic?. Journal of Gastroenterology and Hepatology, 37(1), 39-44.
Journal: Journal of Gastroenterology and Hepatology
Abstract: Fecal microbiota transplantation (FMT) has been used extensively in the treatment of various gastrointestinal and extraintestinal conditions, despite that there are still a lot of missing gaps in our knowledge in the gut microbiota and its behavior. This article describes the unknowns in microbiota biology (undetected microbes, uncertain colonization, unclear mechanisms of action, uncertain indications, unsure long-term efficacy, or side effects). We discuss how these unknowns may affect the therapeutic uses of FMT, and the potentials and caveats of other related microbiota-based therapies. When used as an experimental therapy or last resort in difficult conditions, caution should be taken against inadvertent complications. Clear documentations of post-treatment events should be made mandatory, classified, and graded as in clinical trials. Further robust scientific experiments and properly designed clinical studies are needed.
ISSN: 0815-9319
DOI: 10.1111/jgh.15716
Rights: © 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

Citations 50

Updated on Jan 29, 2023

Web of ScienceTM
Citations 50

Updated on Jan 30, 2023

Page view(s)

Updated on Feb 2, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.