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Title: Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection
Authors: Kali, Suresh Kumar
Dröge, Peter
Murugan, Priyatharshini
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Kali, S. K., Dröge, P. & Murugan, P. (2021). Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection. Microbial Pathogenesis, 158, 105105-.
Journal: Microbial Pathogenesis
Abstract: COVID-19 exhibits a global health threat among the elderly and the population with underlying health conditions. During infection, the host's innate immune response acts as a frontline of defense by releasing cytokines such as type I interferon (IFN α and β) thereby initiating antiviral activity. However, this particular interferon response is interrupted by factors such as SARS-CoV-2 non-structural proteins, aging, diabetes, and germ-line errors eventually making the host more susceptible to illness. Therefore, enhancing the host's innate immune response by administering type I IFN could be an effective treatment against COVID-19. Here, we highlight the importance of innate immune response and the role of IFN β monotherapy against COVID-19.
ISSN: 0882-4010
DOI: 10.1016/j.micpath.2021.105105
Rights: © 2021 Elsevier Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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