Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162019
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dc.contributor.authorYao, Xuemeien_US
dc.contributor.authorLi, Menghuanen_US
dc.contributor.authorLi, Bingen_US
dc.contributor.authorXue, Chenchengen_US
dc.contributor.authorCai, Kaiyongen_US
dc.contributor.authorZhao, Yanlien_US
dc.contributor.authorLuo, Zhongen_US
dc.date.accessioned2022-09-29T06:14:39Z-
dc.date.available2022-09-29T06:14:39Z-
dc.date.issued2020-
dc.identifier.citationYao, X., Li, M., Li, B., Xue, C., Cai, K., Zhao, Y. & Luo, Z. (2020). Tumor-targeted upconverting nanoplatform constructed by host-guest interaction for near-infrared-light-actuated synergistic photodynamic-/chemotherapy. Chemical Engineering Journal, 390, 124516-. https://dx.doi.org/10.1016/j.cej.2020.124516en_US
dc.identifier.issn1385-8947en_US
dc.identifier.urihttps://hdl.handle.net/10356/162019-
dc.description.abstractThe strategic combination of photodynamic therapy and chemotherapy has emerged as a promising treatment option for various tumor indications, which not only expands our understanding of each individual modality but also reveals new opportunities to achieve superadditive benefit via exploring their internal synergy rather than simple mixing. In this study, dual-emissive upconverting nanoparticle (UCNP) was employed to bridge the two treatment regimens to synergistically reinforce the therapeutic efficacy. The UCNP-based drug delivery nanoplatform was first co-loaded with 1,8-dihydroxy-3-methylanthraquinone (DHMA) photosensitizers and UV-activatable camptothecin prodrug (NBCCPT) and then complexed with biofunctional β-cyclodextrin species (β-CD-PEG-LA) via highly specific host-guest interactions to cap the camptothecin prodrug conjugated on the nanoparticle surface. The supramolecularly attached β-CD-PEG-LA could not only enhance the aqueous dispersity of the nanocarriers and prevent DHMA leakage, but also imbues targeting effect against asialoglycoprotein receptor-overexpressing tumor cells. The UCNP core would convert the NIR excitation (980 nm) into localized UV (360 nm) and visible (480 nm) emissions, of which the former would cleave the nitrobenzene linker to restore the cytotoxicity of CPT while the latter could excite the photosensitizer to generate reactive oxygen species (ROS). In addition to the photodynamic damage, the light-generated ROS could also facilitate the endo/lysosomal escape of the endocytosed nanoparticles and improve the overall antitumor potency in a synergistic manner.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationA1883c0005en_US
dc.relationNRF-NRFI2018-03en_US
dc.relation.ispartofChemical Engineering Journalen_US
dc.rights© 2020 Elsevier B.V. All rights reserved.en_US
dc.subjectEngineering::Bioengineeringen_US
dc.titleTumor-targeted upconverting nanoplatform constructed by host-guest interaction for near-infrared-light-actuated synergistic photodynamic-/chemotherapyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1016/j.cej.2020.124516-
dc.identifier.scopus2-s2.0-85079874966-
dc.identifier.volume390en_US
dc.identifier.spage124516en_US
dc.subject.keywordsHost-Guest Interactionen_US
dc.subject.keywordsPhotochemical Internalizationen_US
dc.description.acknowledgementThis research is supported by the National Natural Science Foundation of China (11832008, 51773023, 51602034, 51603024, 51825302, 21734002), National Key R&D Program of China (2016YFC1100300, 2017YFB0702603), Innovation Project on Industrial Generic Key Technologies of Chongqing (cstc2015zdcy-ztzx120003), Natural Science Foundation of Chongqing Municipal Government (cstc2018jcyjAX0368), People's Livelihood Special Innovation Projects of Chongqing CSTC (cstc2017shmsA130071), Fundamental Research Funds for the Central Universities (2018CDQYSM0036), Innovation Team in University of Chongqing Municipal Government (CXTDX201601002), Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A1883c0005) and the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03).en_US
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