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Title: A renal-clearable macromolecular reporter for near-infrared fluorescence imaging of bladder cancer
Authors: Huang, Jiaguo
Jiang, Yuyan
Li, Jingchao
He, Shasha
Huang, Jingsheng
Pu, Kanyi
Keywords: Engineering::Chemical engineering
Issue Date: 2020
Source: Huang, J., Jiang, Y., Li, J., He, S., Huang, J. & Pu, K. (2020). A renal-clearable macromolecular reporter for near-infrared fluorescence imaging of bladder cancer. Angewandte Chemie International Edition, 59(11), 4415-4420.
Project: M408162
Journal: Angewandte Chemie International Edition
Abstract: Bladder cancer (BC) is a prevalent disease with high morbidity and mortality; however, in vivo optical imaging of BC remains challenging because of the lack of cancer-specific optical agents with high renal clearance. Herein, a macromolecular reporter (CyP1) was synthesized for real-time near-infrared fluorescence (NIRF) imaging and urinalysis of BC in living mice. Because of the high renal clearance (ca. 94 % of the injection dosage at 24 h post-injection) and its cancer biomarker (APN=aminopeptidase N) specificity, CyP1 can be efficiently transported to the bladder and specially turn on its NIRF signal to report the detection of BC in living mice. Moreover, CyP1 can be used for optical urinalysis, permitting the ex vivo tracking of tumor progression for therapeutic evaluation and easy translation of CyP2 as an in vitro diagnostic assay. This study not only provides new opportunities for non-invasive diagnosis of BC, but also reveals useful guidelines for the development of molecular reporters for the detection of bladder diseases.
ISSN: 1433-7851
DOI: 10.1002/anie.201911859
Rights: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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