Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162027
Title: Molecularly engineered macrophage-derived exosomes with inflammation tropism and intrinsic heme biosynthesis for atherosclerosis treatment
Authors: Wu, Guanghao
Zhang, Jinfeng
Zhao, Qianru
Zhuang, Wanru
Ding, Jingjing
Zhang, Chi
Gao, Haijun
Pang, Dai-Wen
Pu, Kanyi
Xie, Hai-Yan
Keywords: Engineering::Chemical engineering
Issue Date: 2020
Source: Wu, G., Zhang, J., Zhao, Q., Zhuang, W., Ding, J., Zhang, C., Gao, H., Pang, D., Pu, K. & Xie, H. (2020). Molecularly engineered macrophage-derived exosomes with inflammation tropism and intrinsic heme biosynthesis for atherosclerosis treatment. Angewandte Chemie International Edition, 59(10), 4068-4074. https://dx.doi.org/10.1002/anie.201913700
Journal: Angewandte Chemie International Edition
Abstract: Atherosclerosis (AS) is a major contributor to cardiovascular diseases worldwide, and alleviating inflammation is a promising strategy for AS treatment. Here, we report molecularly engineered M2 macrophage-derived exosomes (M2 Exo) with inflammation-tropism and anti-inflammatory capabilities for AS imaging and therapy. M2 Exo are derived from M2 macrophages and further electroporated with FDA-approved hexyl 5-aminolevulinate hydrochloride (HAL). After systematic administration, the engineered M2 Exo exhibit excellent inflammation-tropism and anti-inflammation effects via the surface-bonded chemokine receptors and the anti-inflammatory cytokines released from the anti-inflammatory M2 macrophages. Moreover, the encapsulated HAL can undergo intrinsic biosynthesis and metabolism of heme to generate anti-inflammatory carbon monoxide and bilirubin, which further enhance the anti-inflammation effects and finally alleviate AS. Meanwhile, the intermediate protoporphyrin IX (PpIX) of the heme biosynthesis pathway permits the fluorescence imaging and tracking of AS.
URI: https://hdl.handle.net/10356/162027
ISSN: 1433-7851
DOI: 10.1002/anie.201913700
Rights: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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