Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162029
Title: Activatable molecular probes for second near-infrared fluorescence, chemiluminescence, and photoacoustic imaging
Authors: Huang, Jiaguo
Pu, Kanyi
Keywords: Engineering::Chemical engineering
Issue Date: 2020
Source: Huang, J. & Pu, K. (2020). Activatable molecular probes for second near-infrared fluorescence, chemiluminescence, and photoacoustic imaging. Angewandte Chemie International Edition, 59(29), 11717-11731. https://dx.doi.org/10.1002/anie.202001783
Project: M4081627
2017-T1-002-134
RG147/17
2019-T1-002-045
MOE2018-T2-2-042
RG125/19
Journal: Angewandte Chemie International Edition
Abstract: Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence in biological tissue between 650-900 nm, conventional optical imaging often has a poor signal-to-background ratio and shallow penetration depth, which limits its ability in deep-tissue in vivo imaging. Second near-infrared fluorescence, chemiluminescence, and photoacoustic imaging modalities mitigate these issues by their respective advantages of minimized light scattering, eliminated external excitation, and ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the ability to change their second near-infrared fluorescence, chemiluminescence, or photoacoustic signals in response to a biomarker have been developed. This Minireview summarizes the molecular design strategies, sensing mechanisms, and imaging applications of AMPs. The potential challenges and perspectives of AMPs in deep-tissue imaging are also discussed.
URI: https://hdl.handle.net/10356/162029
ISSN: 1433-7851
DOI: 10.1002/anie.202001783
Rights: © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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