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Title: Semiconducting polycomplex nanoparticles for photothermal ferrotherapy of cancer
Authors: He, Shasha
Jiang, Yuyan
Li, Jingchao
Pu, Kanyi
Keywords: Engineering::Chemical engineering
Issue Date: 2020
Source: He, S., Jiang, Y., Li, J. & Pu, K. (2020). Semiconducting polycomplex nanoparticles for photothermal ferrotherapy of cancer. Angewandte Chemie International Edition, 59(26), 10633-10638.
Project: M4081627
Journal: Angewandte Chemie International Edition
Abstract: This study reports the development of iron-chelated semiconducting polycomplex nanoparticles (SPFeN) for photoacoustic (PA) imaging-guided photothermal ferrotherapy of cancer. The hybrid polymeric nanoagent comprises a ferroptosis initiator (Fe3+ ) and an amphiphilic semiconducting polycomplex (SPC ) serving as both the photothermal nanotransducer and iron ion chelator. By virtue of poly(ethylene glycol) (PEG) grafting and its small size, SPFeN accumulates in the tumor of living mice after systemic administration, which can be monitored by PA imaging. In the acidic tumor microenvironment, SPFeN generates hydroxyl radicals, leading to ferroptosis; meanwhile, under NIR laser irradiation, it generates localized heat to not only accelerate the Fenton reaction but also implement photothermal therapy. Such a combined photothermal ferrotherapeutic effect of SPFeN leads to minimized dosage of iron compared to previous studies and effectively inhibits the tumor growth in living mice, which is not possible for the controls.
ISSN: 1433-7851
DOI: 10.1002/anie.202003004
Rights: © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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