Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162031
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dc.contributor.authorHe, Shashaen_US
dc.contributor.authorJiang, Yuyanen_US
dc.contributor.authorLi, Jingchaoen_US
dc.contributor.authorPu, Kanyien_US
dc.date.accessioned2022-09-29T08:55:21Z-
dc.date.available2022-09-29T08:55:21Z-
dc.date.issued2020-
dc.identifier.citationHe, S., Jiang, Y., Li, J. & Pu, K. (2020). Semiconducting polycomplex nanoparticles for photothermal ferrotherapy of cancer. Angewandte Chemie International Edition, 59(26), 10633-10638. https://dx.doi.org/10.1002/anie.202003004en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttps://hdl.handle.net/10356/162031-
dc.description.abstractThis study reports the development of iron-chelated semiconducting polycomplex nanoparticles (SPFeN) for photoacoustic (PA) imaging-guided photothermal ferrotherapy of cancer. The hybrid polymeric nanoagent comprises a ferroptosis initiator (Fe3+ ) and an amphiphilic semiconducting polycomplex (SPC ) serving as both the photothermal nanotransducer and iron ion chelator. By virtue of poly(ethylene glycol) (PEG) grafting and its small size, SPFeN accumulates in the tumor of living mice after systemic administration, which can be monitored by PA imaging. In the acidic tumor microenvironment, SPFeN generates hydroxyl radicals, leading to ferroptosis; meanwhile, under NIR laser irradiation, it generates localized heat to not only accelerate the Fenton reaction but also implement photothermal therapy. Such a combined photothermal ferrotherapeutic effect of SPFeN leads to minimized dosage of iron compared to previous studies and effectively inhibits the tumor growth in living mice, which is not possible for the controls.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relationM4081627en_US
dc.relation2017-T1-002-134en_US
dc.relationRG147/17en_US
dc.relation2019-T1-002-045en_US
dc.relationRG125/19en_US
dc.relationMOE2018-T2-2-042en_US
dc.relation.ispartofAngewandte Chemie International Editionen_US
dc.rights© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.en_US
dc.subjectEngineering::Chemical engineeringen_US
dc.titleSemiconducting polycomplex nanoparticles for photothermal ferrotherapy of canceren_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1002/anie.202003004-
dc.identifier.pmid32207214-
dc.identifier.scopus2-s2.0-85083637800-
dc.identifier.issue26en_US
dc.identifier.volume59en_US
dc.identifier.spage10633en_US
dc.identifier.epage10638en_US
dc.subject.keywordsCanceren_US
dc.subject.keywordsFerrotherapyen_US
dc.description.acknowledgementK.P. thanks Nanyang Technological University (Start-Up grant: M4081627) and Singapore Ministry of Education Academic Research Fund Tier 1 (2017-T1-002-134 RG147/17 & 2019-T1-002-045 RG125/19) and Academic Research Fund Tier 2 (MOE2018-T2-2-042) for the financial support.en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
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