Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162044
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dc.contributor.authorHuang, Jiaguoen_US
dc.contributor.authorXian, Shiyunen_US
dc.contributor.authorLiu, Yien_US
dc.contributor.authorChen, Xiaonaen_US
dc.contributor.authorPu, Kanyien_US
dc.contributor.authorWang, Hangxiangen_US
dc.date.accessioned2022-10-03T01:50:05Z-
dc.date.available2022-10-03T01:50:05Z-
dc.date.issued2022-
dc.identifier.citationHuang, J., Xian, S., Liu, Y., Chen, X., Pu, K. & Wang, H. (2022). A renally clearable activatable polymeric nanoprobe for early detection of hepatic ischemia-reperfusion injury. Advanced Materials, 34(24), e2201357-. https://dx.doi.org/10.1002/adma.202201357en_US
dc.identifier.issn0935-9648en_US
dc.identifier.urihttps://hdl.handle.net/10356/162044-
dc.description.abstractAlthough hepatic ischemia-reperfusion injury (IRI) represents a major complication in many clinical settings, it remains a diagnostic dilemma due to its reliance on insensitive assays or invasive biopsy. The development of an activatable polymeric nanoprobe (APNSO ) for real-time in vivo near-infrared fluorescence (NIRF) imaging and urinalysis of hepatic IRI is reported here. APNSO has a backbone comprising renally clearable fluorophore fragments and self-immolative structural units. In the presence of an oxidative stress biomarker (superoxide anion, O2 •- ) during hepatic IRI, APNSO can be fluorescently activated for in vivo NIRF imaging and depolymerized to release renally clearable fluorophores for urinalysis. By virtue of its high hepatic accumulation, sensitive response toward O2 •- , and effective release of renally clearable fluorophores, APNSO -based imaging and urinalysis detect hepatic IRI at least 7 h earlier than typical clinical assays in a mouse model. This study not only provides new opportunities for noninvasive diagnosis of hepatic IRI, but also reveals guidelines for the development of optical nanosensors for early urinalysis.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relation2019-T1-002-045en_US
dc.relationRG125/19en_US
dc.relationMOE2018-T2-2-042en_US
dc.relationMOE-T2EP30220-0010en_US
dc.relation.ispartofAdvanced Materialsen_US
dc.rights© 2022 Wiley-VCH GmbH. All rights reserved.en_US
dc.subjectEngineering::Bioengineeringen_US
dc.titleA renally clearable activatable polymeric nanoprobe for early detection of hepatic ischemia-reperfusion injuryen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1002/adma.202201357-
dc.identifier.pmid35436014-
dc.identifier.scopus2-s2.0-85129985741-
dc.identifier.issue24en_US
dc.identifier.volume34en_US
dc.identifier.spagee2201357en_US
dc.subject.keywordsActivatable Polymeric Nanoprobeen_US
dc.subject.keywordsFluorescence Imagingen_US
dc.description.acknowledgementK.P. thanks Singapore Ministry of Education, Academic Research Fund Tier 1 (2019-T1-002-045, RG125/19), Academic Research Fund Tier 2 (MOE2018-T2-2-042 and MOE-T2EP30220-0010) for the financial support. J.H. acknowledges the support from the start-up funding of Sun Yat-Sen University. H.W. thanks Zhejiang Provincial Natural Science Foundation of China (LR19H160002), National Natural Science Foundation of China (82073296 and 81773193), Research Project of Jinan Microecological Biomedicine Shandong Laboratory (JNL-2022010B) for the financial support.en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
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