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Title: Activatable cancer sono-immunotherapy using semiconducting polymer nanobodies
Authors: Zeng, Ziling
Zhang, Chi
He, Shasha
Li, Jingchao
Pu, Kanyi
Keywords: Science::Medicine
Issue Date: 2022
Source: Zeng, Z., Zhang, C., He, S., Li, J. & Pu, K. (2022). Activatable cancer sono-immunotherapy using semiconducting polymer nanobodies. Advanced Materials, 34(28), e2203246-.
Project: 2019-T1-002-045 
SERC A18A8b005
Journal: Advanced Materials
Abstract: Despite the great promises of sonodynamic therapy (SDT) in combination cancer therapy, its clinical applications are hindered by the "always-on" pharmacological activities of therapeutic agents and the lack of efficient sonosensitizers. Herein, the development of semiconducting polymers as efficient sonosensitizers and further development of sono-immunotherapeutic nanobodies (SPNAb ) for activatable cancer sono-immunotherapy are reported. Conjugation of anti-CTLA-4 antibodies onto the polymer nanoparticles through a 1 O2 -cleavable linker affords SPNAb with relatively low CTLA-4 binding affinity. Upon sono-irradiation, SPNAb generates 1 O2 not only to elicit a sonodynamic effect to induce immunogenic cell death, but also to release anti-CTLA-4 antibodies and trigger in situ checkpoint blockade. Such a synergistic therapeutic action mediated by SPNAb modulates the tumoricidal function of T-cell immunity by promoting the proliferation of cytotoxic T lymphocytes and depleting immunosuppressive regulatory T cells, resulting in effective tumor regression, metastasis inhibition, durable immunological memory, and prevention of relapse. Therefore, this study represents a proof-of-concept sonodynamic strategy using semiconducting polymers for precise spatiotemporal control over immunotherapy.
ISSN: 0935-9648
DOI: 10.1002/adma.202203246
Rights: © 2022 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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