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Title: Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes
Authors: Zhang, Weiyun
Liu, Jiawei
Li, Xuyu
Zheng, Yue
Chen, Lianfu
Wang, Dongdong
Foda, Mohamed Frahat
Ma, Zhaoyu
Zhao, Yanli
Han, Heyou
Keywords: Science::Chemistry
Issue Date: 2021
Source: Zhang, W., Liu, J., Li, X., Zheng, Y., Chen, L., Wang, D., Foda, M. F., Ma, Z., Zhao, Y. & Han, H. (2021). Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes. ACS Nano, 15(12), 19321-19333.
Project: NRF-NRFI2018-03 
Journal: ACS Nano 
Abstract: Chemodynamic therapy (CDT) destroys cancer cells by converting H2O2 or O2 into reactive oxygen species (ROS), but its therapeutic efficacy is restricted by the antioxidant capacity of tumor. Previous solutions focused on strengthening the nanodrugs with the ability to increase ROS production or weaken the antioxidant capacity of cancer cells. Conversely, we here develop a mild nanodrug with negligible side effects. Specifically, the Au@Pt nanozyme decorated on a bacterial surface (Bac-Au@Pt) is reported to achieve precise CDT. Due to the tumor targeting ability of bacteria and catalytic property of Au@Pt nanozyme under acidic conditions, this nanosystem can release ROS to tumor cells effectively. In addition, the interferon gamma released by T cells specifically decreases the intracellular reductants in tumor cells, while having no obvious effect on normal cells. Therefore, a low dose of Bac-Au@Pt achieves a satisfactory therapeutic efficacy to tumor cells and is nontoxic to normal cells even at their acidic components. This nanosystem enables CDT and immunotherapy to mutually benefit and improve by each other, providing a promising strategy to achieve high anticancer efficacy even with a low dose usage.
ISSN: 1936-0851
DOI: 10.1021/acsnano.1c05605
Rights: © 2021 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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