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Title: Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy
Authors: Chen, Yun
He, Peiying
Jana, Deblin
Wang, Dongdong
Wang, Menghao
Yu, Peiyuan
Zhu, Wei
Zhao, Yanli
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Chen, Y., He, P., Jana, D., Wang, D., Wang, M., Yu, P., Zhu, W. & Zhao, Y. (2022). Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy. Advanced Materials, 34(21), 2201706-.
Project: A20E5c0081
Journal: Advanced Materials
Abstract: Although photothermal immunotherapy (PTI) is a compelling strategy for tumor therapy, the development of promising photothermal agents to overcome the insufficient immunogenicity of tumor cells and the poor immune response encountered in PTI is still challenging. Herein, commercial small-molecule-based organic metal adjuvants (OMAs) are presented, with second near-infrared photoacoustic and photothermal properties as well as the ability to perturb redox homeostasis to potentiate immunogenicity and immune responsiveness. OMAs, assembled from charge-transfer complexes and characterized by a broad substrate scope, high accessibility, and flexibly tuned optical properties, demonstrate strong phototherapeutic and adjuvant abilities via the depletion of glutathione and cysteine, and subsequently elicit systemic immunity by evoking immunogenic cell death, promoting dendritic cell maturation, and increasing T cell infiltration. Furthermore, programmed cell death protein 1 antibody can be employed to synergize with OMAs to suppress tumor immune evasion and ultimately improve the treatment outcomes. This study unlocks new paradigms to provide a versatile OMA-based scaffold for future practical applications.
ISSN: 0935-9648
DOI: 10.1002/adma.202201706
Rights: © 2022 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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