Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162065
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dc.contributor.authorLiu, Jingen_US
dc.contributor.authorHe, Shashaen_US
dc.contributor.authorLuo, Yinglien_US
dc.contributor.authorZhang, Yueen_US
dc.contributor.authorDu, Xiaojiaoen_US
dc.contributor.authorXu, Chengen_US
dc.contributor.authorPu, Kanyien_US
dc.contributor.authorWang, Junen_US
dc.date.accessioned2022-10-03T05:29:18Z-
dc.date.available2022-10-03T05:29:18Z-
dc.date.issued2022-
dc.identifier.citationLiu, J., He, S., Luo, Y., Zhang, Y., Du, X., Xu, C., Pu, K. & Wang, J. (2022). Tumor-microenvironment-activatable polymer nano-immunomodulator for precision cancer photoimmunotherapy. Advanced Materials, 34(8), e2106654-. https://dx.doi.org/10.1002/adma.202106654en_US
dc.identifier.issn0935-9648en_US
dc.identifier.urihttps://hdl.handle.net/10356/162065-
dc.description.abstractCancer nanomedicine combined with immunotherapy has become a promising strategy for treating cancer in terms of safety and potency; however, precise regulation of the activation of antitumor immunity remains challenging. Herein, a smart semiconducting polymer nano-immunomodulator (SPNI), which responds to the acidic tumor microenvironment (TME), for precision photodynamic immunotherapy of cancer, is reported. The SPNI is self-assembled by a near-infrared (NIR)-absorbing semiconducting polymer and an amphipathic polymer conjugated with a Toll-like receptor 7 (TLR7) agonist via an acid-labile linker. Upon arrival at tumor site, SPNI undergoes hydrolysis and triggers an efficient liberation of TLR7 agonist in response to the acidic TME for dendritic cell activation. Moreover, SPNI exerts photodynamic effects for direct tumor eradication and immunogenic cancer cell death under NIR photoirradiation. The synergistic action of released immunogenic factors and acidic-TME-activated TLR7 agonist can serve as an in situ generated cancer vaccine to evoke strong antitumor activities. Notably, such localized immune activation boosts systemic antitumor immune responses, resulting in enhanced cytotoxic CD8+ T infiltration to inhibit tumor growth and metastasis. Thereby, this work presents a general strategy to devise prodrug of immunotherapeutics for precise regulation of cancer immunotherapy.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relation2019-T1-002-045en_US
dc.relationRG125/19en_US
dc.relationMOE2018-T2-2-042en_US
dc.relationSERC A18A8b0059en_US
dc.relation.ispartofAdvanced Materialsen_US
dc.rights© 2022 Wiley-VCH GmbH. All rights reserved.en_US
dc.subjectEngineering::Bioengineeringen_US
dc.titleTumor-microenvironment-activatable polymer nano-immunomodulator for precision cancer photoimmunotherapyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1002/adma.202106654-
dc.identifier.pmid34854147-
dc.identifier.scopus2-s2.0-85122741697-
dc.identifier.issue8en_US
dc.identifier.volume34en_US
dc.identifier.spagee2106654en_US
dc.subject.keywordsImmunotherapyen_US
dc.subject.keywordsOrganic Nanoparticlesen_US
dc.description.acknowledgementK.P. would like to acknowledge financial support from Singapore Ministry of Education, Academic Research Fund Tier 1 (2019-T1-002-045, RG125/19), Academic Research Fund Tier 2 (MOE2018-T2-2-042), and A*STAR SERC AME Programmatic Fund (SERC A18A8b0059). J.W. would like to acknowledge financial support from the National Key R & D Program of China (2017YFA0205600), the National Natural Science Foundation of China (51633008, 32071378, 31870996), the Science and Technology Program of Guangzhou (202103030004), Guangdong Provincial Pearl River Talents Program (2017GC010713, 2017GC010482), the China Postdoctoral Science Foundation (2021M701235), and the Natural Science Foundation of Guangdong Province, China (No. 2021A1515010592) for the financial support.en_US
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