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dc.contributor.authorMa, Yiyuanen_US
dc.contributor.authorKoh, Cheryl Jie Yanen_US
dc.contributor.authorLim, Hong Kiten_US
dc.contributor.authorShi, Pujiangen_US
dc.contributor.authorTay, Chor Yongen_US
dc.identifier.citationMa, Y., Koh, C. J. Y., Lim, H. K., Shi, P. & Tay, C. Y. (2022). Elucidating the size-dependency of in vitro digested polystyrene microplastics on human intestinal cells health and function. Macromolecular Chemistry and Physics, 223(13), 2100454-.
dc.description.abstractThe prevalence of microplastics (MPs) contamination in a broad spectrum of potable water sources has raised significant environmental and public health concerns. While evidence of ingested MPs bioaccumulation in the gastrointestinal tract (GIT) of aquatic and terrestrial organisms is mounting, the understanding of the effects of MPs on human gastrointestinal health remains scant. Herein, the potential deleterious biological effects of pristine and in vitro digested polystyrene (PS) MPs of varying sizes (i.e., 0.1, 1, and 10 µm) are systematically examined over a wide concentration range of 25–400 µg mL−1 on two human intestinal cell lines, namely Caco-2 and NCM 460. Specifically, significant internalization of 0.1 and 1 µm PS -MPs have been observed in both cell types 24 h postexposure. However, multiparametric dose and time-dependent analysis encompassing cell viability, reactive oxygen species (ROS), and nutrient absorption/metabolism measurement revealed no significant adversarial outcomes. Interestingly, it is found that the 0.1 µm PS-MPs can perturb redox homeostasis in NCM460 but not in Caco-2 cells. Based on the in vitro experimental boundaries and findings, it is concluded that ingested PS-MPs pose little acute cytotoxic harm to human gastrointestinal health.en_US
dc.relation.ispartofMacromolecular Chemistry and Physicsen_US
dc.rights© 2022 Wiley-VCH GmbH. All rights reserved.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleElucidating the size-dependency of in vitro digested polystyrene microplastics on human intestinal cells health and functionen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.researchNanyang Environment and Water Research Instituteen_US
dc.contributor.researchEnergy Research Institute @ NTU (ERI@N)en_US
dc.contributor.researchEnvironmental Chemistry and Materials Centreen_US
dc.contributor.researchCenter for Sustainable Materials (SunSmart)en_US
dc.subject.keywordsIntestinal Toxicityen_US
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