Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162112
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dc.contributor.authorTan, Yong Zenen_US
dc.contributor.authorZamani, Farhaden_US
dc.contributor.authorTian, Juen_US
dc.contributor.authorChew, Jia Weien_US
dc.date.accessioned2022-10-04T07:12:39Z-
dc.date.available2022-10-04T07:12:39Z-
dc.date.issued2022-
dc.identifier.citationTan, Y. Z., Zamani, F., Tian, J. & Chew, J. W. (2022). Coriolis efect particles segregator (CEPS): the feasibility of scaling up lab‑on‑a‑chip separation. Microfluidics and Nanofluidics, 26(2), 14-. https://dx.doi.org/10.1007/s10404-022-02521-7en_US
dc.identifier.issn1613-4982en_US
dc.identifier.urihttps://hdl.handle.net/10356/162112-
dc.description.abstractEffective separation is critical in a wide range of applications. The focus here is on disease diagnosis in the healthcare industry and blood constituent separation in the medical industry, whereby lab-on-a-chip devices are generally limited by low throughput, which restricts separation on a practical scale. In this study, we conceive a novel Coriolis Effect Particles Segregator (CEPS), in which Coriolis force is harnessed as the key driving force for separation in a simple milli-fluidic straight-through channel and milliliters (rather than microliters) of fluids can be readily handled. First, Matlab simulations based on theoretical equations prove that perfect separation of 8 and 15 μm particles is possible. Then, Comsol simulations were performed to ascertain if an off-the-shelf milli-fluidic glass tube, coupled with Y-tube fittings as inlets and outlets, can be used. Finally, to provide proof-of-concept, a prototype was designed and built to demonstrate the practical feasibility of the CEPS. In contrast to theoretical calculations, separation was not as perfect, due to pressure differential at the outlets, need to further optimize the operating parameters (e.g., rotation speed, flow rates), adhesion of particles to channel wall, and vibration effects of the assembled setup. This study showcases the feasibility of scaling up the lab-on-a-chip design into a more practical-scale CEPS, providing a new platform for separations particularly of blood constituents (e.g., red blood cells, circulating tumor cells).en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relationMOE/2018/MDT34en_US
dc.relationA20B3a0070en_US
dc.relationA2083c0049en_US
dc.relation2019-T1-002- 065en_US
dc.relationRG100/19en_US
dc.relationMOE-MOET2EP10120-0001en_US
dc.relation.ispartofMicrofluidics and Nanofluidicsen_US
dc.rights© 2022 The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. All rights reserved.en_US
dc.subjectEngineering::Chemical engineeringen_US
dc.titleCoriolis efect particles segregator (CEPS): the feasibility of scaling up lab‑on‑a‑chip separationen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.researchSingapore Membrane Technology Centreen_US
dc.identifier.doi10.1007/s10404-022-02521-7-
dc.identifier.scopus2-s2.0-85123822609-
dc.identifier.issue2en_US
dc.identifier.volume26en_US
dc.identifier.spage14en_US
dc.subject.keywordsLab on a Chipen_US
dc.subject.keywordsParticle Separationen_US
dc.description.acknowledgementThis work was supported by the Nanyang Technological University (Singapore) Ntuitive Multidisciplinary Grant (MOE/2018/MDT34), A*STAR (Singapore) Advanced Manufacturing and Engineering (AME) under its Pharma Innovation Programme Singapore (PIPS) program (A20B3a0070) and A*STAR (Singapore) Advanced Manufacturing and Engineering (AME) under its Individual Research Grant (IRG) program (A2083c0049), the Singapore Ministry of Education Academic Research Fund Tier 1 Grant (2019-T1-002- 065; RG100/19) and the Singapore Ministry of Education Academic Research Fund Tier 2 Grant (MOE-MOET2EP10120-0001).en_US
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