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Title: Lipid nanoparticle technologies for nucleic acid delivery: a nanoarchitectonics perspective
Authors: Ferhan, Abdul Rahim
Park, Soohyun
Park, Hyeonjin
Tae, Hyunhyuk
Jackman, Joshua A.
Cho, Nam-Joon
Keywords: Engineering::Materials
Issue Date: 2022
Source: Ferhan, A. R., Park, S., Park, H., Tae, H., Jackman, J. A. & Cho, N. (2022). Lipid nanoparticle technologies for nucleic acid delivery: a nanoarchitectonics perspective. Advanced Functional Materials, 32(37), 2203669-.
Project: 2020-T1-002-032 (RG111/20)
CA- LUCA AICell REQ0239282
Journal: Advanced Functional Materials
Abstract: Lipid-based nanoparticles have emerged as a clinically viable platform technology to deliver nucleic acids for a wide range of healthcare applications. Within this scope, one of the most exciting areas of recent progress and future innovation potential lies in the material science of lipid-based nanoparticles, both to refine existing nanoparticle strategies and to develop new ones. Herein, the latest efforts to develop next-generation lipid-based nanoparticles are covered by taking a nanoarchitectonics perspective and the design, nucleic acid encapsulation methods, scalable production, and application prospects are critically analyzed for three classes of lipid-based nanoparticles: 1) traditional lipid nanoparticles (LNPs); 2) lipoplexes; and 3) bicelles. Particular focus is placed on rationalizing how molecular self-assembly principles enable advanced functionalities along with comparing and contrasting the different nanoarchitectures. The current development status of each class of lipid-based nanoparticle is also evaluated and possible future directions in terms of overcoming clinical translation challenges and realizing new application opportunities are suggested.
ISSN: 1616-301X
DOI: 10.1002/adfm.202203669
Rights: © 2022 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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