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Title: A dual-locked activatable phototheranostic probe for biomarker-regulated photodynamic and photothermal cancer therapy
Authors: Wei, Xin
Zhang, Chi
He, Shasha
Huang, Jiaguo
Huang, Jingsheng
Liew, Si Si
Zeng, Ziling
Pu, Kanyi
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Wei, X., Zhang, C., He, S., Huang, J., Huang, J., Liew, S. S., Zeng, Z. & Pu, K. (2022). A dual-locked activatable phototheranostic probe for biomarker-regulated photodynamic and photothermal cancer therapy. Angewandte Chemie (International Ed. in English), 61(26), e202202966-.
Project: 2019-T1-002-045 
SERC A18A8b0059
Journal: Angewandte Chemie (International ed. in English)
Abstract: Activatable phototheranostics holds promise for precision cancer treatment owing to the "turn-on" signals and therapeutic effects. However, most activatable phototheranostic probes only possess photodynamic therapy (PDT) or photothermal therapy (PTT), which suffer from poor therapeutic efficacy due to deficient cellular oxygen and complex tumor microenvironment. We herein report a dual-locked activatable phototheranostic probe that activates near-infrared fluorescence (NIRF) signals in tumor, triggers PDT in response to a tumor-periphery biomarker, and switches from PDT to PTT upon detecting a tumor-core-hypoxia biomarker. This PDT-PTT auto-regulated probe exhibits complete tumor ablation under the photoirradiation of a single laser source by producing cytotoxic singlet oxygen at the tumor periphery and generating hyperthermia at tumor-core where is too hypoxic for PDT. This dual-locked probe represents a promising molecular design approach toward precise cancer phototheranostics.
ISSN: 1433-7851
DOI: 10.1002/anie.202202966
Rights: © 2022 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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