Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162212
Title: An activatable polymeric nanoprobe for fluorescence and photoacoustic imaging of tumor-associated neutrophils in cancer immunotherapy
Authors: Zhang, Yan
He, Shasha
Xu, Cheng
Jiang, Yue
Miao, Qingqing
Pu, Kanyi
Keywords: Engineering::Bioengineering
Science::Medicine
Issue Date: 2022
Source: Zhang, Y., He, S., Xu, C., Jiang, Y., Miao, Q. & Pu, K. (2022). An activatable polymeric nanoprobe for fluorescence and photoacoustic imaging of tumor-associated neutrophils in cancer immunotherapy. Angewandte Chemie (International Ed. in English), 61(27), e202203184-. https://dx.doi.org/10.1002/anie.202203184
Project: 2019-T1-002-045 
RG125/19 
RT05/20
MOE2018-T2-2-042 
MOE-T2EP30220-0010
Journal: Angewandte Chemie (International ed. in English)
Abstract: Imaging to evaluate tumor-associated neutrophils (TANs) is imperative for cancer immunotherapy but remains challenging. We herein report an activatable semiconducting polymer nanoprobe (SPCy) for near-infrared fluorescence (NIRF) and photoacoustic (PA) imaging of neutrophil elastase (NE), a biomarker of TANs. SPCy comprises a semiconducting polymer conjugated with a hemicyanine (hemi-Cy) dye caged by a NE-cleavable peptide as the side chain. After systemic administration, SPCy passively targets the tumor and reacts with NE to "uncage" the hemi-Cy, leading to enhanced NIRF and PA signals of the hemi-Cy but unchanged signals of the SP. Such NE-activated ratiometric NIRF and enhanced PA signals of SPCy correlate with the intratumoral population of TANs. Thus, this study not only presents the first TAN-specific PA probe, but also provides a general molecular design strategy for PA imaging of other immune-related biomarkers to facilitate screening of cancer immunotherapeutics.
URI: https://hdl.handle.net/10356/162212
ISSN: 1433-7851
DOI: 10.1002/anie.202203184
Rights: © 2022 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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