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Title: Semiconducting polymer nano-regulators with cascading activation for photodynamic cancer immunotherapy
Authors: He, Shasha
Liu, Jing
Zhang, Chi
Wang, Jun
Pu, Kanyi
Keywords: Science::Medicine
Issue Date: 2022
Source: He, S., Liu, J., Zhang, C., Wang, J. & Pu, K. (2022). Semiconducting polymer nano-regulators with cascading activation for photodynamic cancer immunotherapy. Angewandte Chemie (International Ed. in English), 61(10), e202116669-.
Project: 2019-T1-002-045 
SERC A18A8b0059
Journal: Angewandte Chemie (International ed. in English)
Abstract: Combination photoimmunotherapy holds promise for tumor suppression; however, smart phototherapeutic agents that only activate their immune pharmaceutical action in tumors have been rarely developed. Herein, we report a semiconducting polymer (SP) nano-regulator (SPNT ) with cascading activation for combinational photodynamic cancer immunotherapy. SPNT comprises an immunoregulator (M-Trp: 1-methyltryptophan) conjugating to the side chain of the SP backbone via an apoptotic biomarker-cleavable linker. Under near-infrared photoirradiation, SPNT produces singlet oxygen to induce immunogenic apoptosis. Concurrently, an apoptotic biomarker is upregulated, which triggers the specific cleavage of M-Trp for indoleamine 2,3-dioxygenase (IDO) activity inhibition, regulatory T cells reduction and cytotoxic T lymphocytes infiltration. SPNT -mediated combination photodynamic immunotherapy thus reprograms the tumor immune microenvironment, resulting in efficient suppression of tumors, and inhibition of lung metastasis.
ISSN: 1433-7851
DOI: 10.1002/anie.202116669
Rights: © 2021 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles
SCBE Journal Articles
SPMS Journal Articles

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