Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162230
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dc.contributor.authorGoh, Jeffreyen_US
dc.contributor.authorOng, Seng Kheongen_US
dc.contributor.authorTan, Yan Shengen_US
dc.contributor.authorLoh, Teck-Pengen_US
dc.date.accessioned2022-10-10T07:50:32Z-
dc.date.available2022-10-10T07:50:32Z-
dc.date.issued2022-
dc.identifier.citationGoh, J., Ong, S. K., Tan, Y. S. & Loh, T. (2022). Catalyst-free C-N bond formation under biocompatible reaction conditions. Green Chemistry, 24(8), 3321-3325. https://dx.doi.org/10.1039/d2gc00027jen_US
dc.identifier.issn1463-9262en_US
dc.identifier.urihttps://hdl.handle.net/10356/162230-
dc.description.abstractA C-N bond formation reaction under biocompatible conditions for the amination of allenic ketone compounds to access a diversity of β-keto enamines is developed. This reaction is atom economical, green, and highly regioselective and works well with many structurally important amines such as amino sugar and amino acid esters or peptides. A wide array of β-keto enamines was obtained in modest to excellent yields with wide functional group tolerance using this protocol. A gram-scale synthesis of an anti-microbial agent was also realized using this strategy under green reaction conditions.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relationRG107/19en_US
dc.relationRG11/20en_US
dc.relationRT14/20en_US
dc.relation.ispartofGreen Chemistryen_US
dc.rights© 2022 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.en_US
dc.subjectScience::Chemistryen_US
dc.titleCatalyst-free C-N bond formation under biocompatible reaction conditionsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1039/d2gc00027j-
dc.description.versionPublished versionen_US
dc.identifier.scopus2-s2.0-85129284897-
dc.identifier.issue8en_US
dc.identifier.volume24en_US
dc.identifier.spage3321en_US
dc.identifier.epage3325en_US
dc.subject.keywordsAmino Acid Estersen_US
dc.subject.keywordsBond Formationen_US
dc.description.acknowledgementThe authors gratefully acknowledge the financial support from the Distinguished University Professor grant (Nanyang Technological University, Singapore), AcRF Tier 1 grants from the Ministry of Education of Singapore (RG107/19, RG11/20 and RT14/20), and the Agency for Science, Technology and Research (A*Star) under its MTC Individual Research Grant (IRG).en_US
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