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Title: Catalyst-free C-N bond formation under biocompatible reaction conditions
Authors: Goh, Jeffrey
Ong, Seng Kheong
Tan, Yan Sheng
Loh, Teck-Peng
Keywords: Science::Chemistry
Issue Date: 2022
Source: Goh, J., Ong, S. K., Tan, Y. S. & Loh, T. (2022). Catalyst-free C-N bond formation under biocompatible reaction conditions. Green Chemistry, 24(8), 3321-3325.
Project: RG107/19
Journal: Green Chemistry
Abstract: A C-N bond formation reaction under biocompatible conditions for the amination of allenic ketone compounds to access a diversity of β-keto enamines is developed. This reaction is atom economical, green, and highly regioselective and works well with many structurally important amines such as amino sugar and amino acid esters or peptides. A wide array of β-keto enamines was obtained in modest to excellent yields with wide functional group tolerance using this protocol. A gram-scale synthesis of an anti-microbial agent was also realized using this strategy under green reaction conditions.
ISSN: 1463-9262
DOI: 10.1039/d2gc00027j
Rights: © 2022 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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