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Title: Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection
Authors: Huang, Jiaguo
Chen, Xiaona
Jiang, Yuyan
Zhang, Chi
He, Shasha
Wang, Hangxiang
Pu, Kanyi
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Huang, J., Chen, X., Jiang, Y., Zhang, C., He, S., Wang, H. & Pu, K. (2022). Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection. Nature Materials, 21(5), 598-607.
Project: 2019-T1-002-045 RG125/19
Journal: Nature Materials 
Abstract: Optical nanoparticles are promising diagnostic tools; however, their shallow optical imaging depth and slow clearance from the body have impeded their use for in vivo disease detection. To address these limitations, we develop activatable polyfluorophore nanosensors with biomarker-triggered nanoparticle-to-molecule pharmacokinetic conversion and near-infrared fluorogenic turn-on response. Activatable polyfluorophore nanosensors can accumulate at the disease site and react with disease-associated proteases to undergo in situ enzyme-catalysed depolymerization. This disease-specific interaction liberates renal-clearable fluorogenic fragments from activatable polyfluorophore nanosensors for non-invasive longitudinal urinalysis and outperforms the gold standard blood and urine assays, providing a level of sensitivity and specificity comparable to those of invasive biopsy and flow cytometry analysis. In rodent models, activatable polyfluorophore nanosensors enable ultrasensitive detection of tumours (1.6 mm diameter) and early diagnosis of acute liver allograft rejection. We anticipate that our modular nanosensor platform may be applied for early diagnosis of a range of diseases via a simple urine test.
ISSN: 1476-1122
DOI: 10.1038/s41563-022-01224-2
Rights: © 2022 The Author(s), under exclusive licence to Springer Nature Limited. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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