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Title: A plasmonic supramolecular nanohybrid as a contrast agent for site-selective computed tomography imaging of tumor
Authors: Bindra, Anivind Kaur
Sreejith, Sivaramapanicker
Prasad, Rajendra
Gorain, Mahadeo
Thomas, Rijil
Jana, Deblin
Nai, Mui Hoon
Wang, Dongdong
Tharayil, Abhimanyu
Kundu, Gopal C.
Srivastava, Rohit
Thomas, Sabu
Lim, Chwee Teck
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2022
Source: Bindra, A. K., Sreejith, S., Prasad, R., Gorain, M., Thomas, R., Jana, D., Nai, M. H., Wang, D., Tharayil, A., Kundu, G. C., Srivastava, R., Thomas, S., Lim, C. T. & Zhao, Y. (2022). A plasmonic supramolecular nanohybrid as a contrast agent for site-selective computed tomography imaging of tumor. Advanced Functional Materials, 32(12), 2110575-.
Project: A20E5c0081
Journal: Advanced Functional Materials
Abstract: Design of organic–inorganic hybrids by anchoring of plasmonic materials such as gold nanoparticles (AuNPs) on self-assembled organic substrates is useful but challenging. Herein, in situ anchoring of plasmonic nanoparticles on the surface of a designed spherical assembly via Au-S bond formation is presented. First, a thiol tailed pyrene derivative (2) undergoes solvent dependent self-assembly, transforming into an organic spherical aggregate (2agg). The thiol (-SH) rich surface of the organic assembly allows cumulative anchoring of AuNPs on the surface to form an organic–inorganic hybrid (Au@2agg). Further coating of biocompatible polyethylene glycol (PEG) leads to the construction of the final multicomponent system (PEG-Au@2agg) exhibiting morphological and spectroscopic features. The potential of PEG-Au@2agg as a bioprobe and a contrast agent is investigated by X-ray computed tomography (CT) experiments in vivo. High X-ray attenuation of directly anchored AuNP clusters on the surface of this supramolecular nanohybrids enhances the X-ray CT contrast and allows tracing of site-selective accumulation in mouse 4T1 breast tumor. Thus, this approach of designing organic–inorganic nanohybrids paves the way for developing future intelligent multifunctional nanosystems capable of cancer detection and imaging.
ISSN: 1616-301X
DOI: 10.1002/adfm.202110575
Rights: © 2021 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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