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dc.contributor.authorZhang, Qiuhongen_US
dc.contributor.authorHe, Meijuanen_US
dc.contributor.authorZhang, Xiaodongen_US
dc.contributor.authorYu, Hongweien_US
dc.contributor.authorLiu, Jiaweien_US
dc.contributor.authorGuo, Yien_US
dc.contributor.authorZhang, Junminen_US
dc.contributor.authorRen, Xiangzhongen_US
dc.contributor.authorWang, Hanen_US
dc.contributor.authorZhao, Yanlien_US
dc.identifier.citationZhang, Q., He, M., Zhang, X., Yu, H., Liu, J., Guo, Y., Zhang, J., Ren, X., Wang, H. & Zhao, Y. (2022). Tumor microenvironment activated chemodynamic–photodynamic therapy by multistage self-assembly engineered protein nanomedicine. Advanced Functional Materials, 32(17), 2112251-.
dc.description.abstractWhile cytotoxic reactive oxygen species (ROS) play an important role in fighting cancer, developing an activable ROS-generating system to achieve highly specific cancer therapy with minimum side effects to normal tissues remains challenging. This work reports the development of a tumor microenvironment-activable ROS-generating system via multistage self-assembly engineered protein-based nanomedicine containing cascade enzymes and photosensitizers. The multistage self-assembly-induced aggregation not only prevents the premature exposure of cascade enzymes to produce toxic by-products in noncancerous sites, but also quenches the photosensitizers to diminish skin phototoxicity, contributing to effective self-protection of normal tissues. Once triggered by the intratumoral reduction microenvironment, the aggregation effect is unlocked to expose cascade enzymes and recover the photosensitivity, which can decompose intratumor glucose for hydroxyl radical generation and respond to external laser irradiation for singlet oxygen production respectively, realizing tumor-specific chemodynamic–photodynamic combinational therapy. This work demonstrates a protein-based multistage self-assembly approach for ROS-mediated cancer-specific therapy with effective self-protection, offering a powerful strategy for nanomedicine design and more precise cancer therapy.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.relation.ispartofAdvanced Functional Materialsen_US
dc.rights© 2022 Wiley-VCH GmbH. All rights reserved.en_US
dc.titleTumor microenvironment activated chemodynamic–photodynamic therapy by multistage self-assembly engineered protein nanomedicineen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.subject.keywordsChemodynamic Therapyen_US
dc.subject.keywordsPhotodynamic Therapyen_US
dc.description.acknowledgementThis research is supported by the National Natural Science Foundation of China (21671136 and 81871400), the Project of Department of Education of Guangdong Province (2020KTSCX116), the Shenzhen Science and Technology Project Program (JCYJ20190808144413257 and 20200812202943001), the Principal Foundation of Shenzhen University (8570700000307), and the Program of Shanghai Education Commission (202101070002E00085). This research is also supported by the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081) and the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03). The authors gratefully acknowledge the support from the Instrumental Analysis Centre of Shenzhen University.en_US
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