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Title: Photodynamic bubble-generating microneedles for enhanced transdermal cancer therapy
Authors: Ning, Xiaoyu
Chen, Si
Yang, Yating
Hwang, Jangsun
Wiraja, Christian
Zhang, Chi
Liu, Wei
Liu, Linbo
Xu, Chenjie
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: Ning, X., Chen, S., Yang, Y., Hwang, J., Wiraja, C., Zhang, C., Liu, W., Liu, L. & Xu, C. (2021). Photodynamic bubble-generating microneedles for enhanced transdermal cancer therapy. ACS Applied Polymer Materials, 3(12), 6502-6512.
Project: A18A8b0059 
Journal: ACS Applied Polymer Materials 
Abstract: Active bubble-generating microneedles (MNs) upon skin interstitial fluid (ISF) contact facilitate deeper and more efficient delivery of intradermal therapeutics. However, bubble-generating MN platforms are sensitive to moisture, which limits their variety to load various functional drugs. This article presents a frozen immersion method that facilitates both hydrophobic and hydrophilic drug loading onto bubble-generating MNs without compromising both drug and MN properties. The formed bubbles upon ISF contact induce distinct vortex flow that produces a propulsion force to enhance drug transportation. The efficiency of transdermal drug delivery is further enhanced by sonophoresis. The drug delivery efficiency of this platform is first evaluated ex vivo using fresh mouse skins and human keloid tissues. Later, in the tumor-bearing mouse model, the platform enhances the skin penetration of photosensitizers (i.e., methylene blue) and correspondingly improves the efficacy of photodynamic therapy.
ISSN: 2637-6105
DOI: 10.1021/acsapm.1c01219
Schools: School of Electrical and Electronic Engineering 
Interdisciplinary Graduate School (IGS) 
School of Chemical and Biomedical Engineering 
Research Centres: NTU Institute for Health Technologies 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Polymer Materials, copyright © 2021 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles
IGS Journal Articles
SCBE Journal Articles

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