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Title: Characterisation and functional study of activation function 1 (AF-1) of progesterone receptor in mouse model
Authors: Lee, Shi Hao
Keywords: Science::Biological sciences::Molecular biology
Issue Date: 2022
Publisher: Nanyang Technological University
Source: Lee, S. H. (2022). Characterisation and functional study of activation function 1 (AF-1) of progesterone receptor in mouse model. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Progesterone receptor (PR) is a master regulator in many female reproductive functions. In the uterus, PR regulates its function through antagonistic as well as synergistic interplays with estrogen receptors. PR also regulates mammary gland development especially during pregnancy and puberty. While PR action is primarily mediate through activation functions 1 and 2 (AF-1 and AF-2), their physiological significance is unknown. We report the first study of AF1 function in mice. Mutant PR AF-1 mice displayed uterine physiological defects, infertility coupled with impaired implantation and decidualisation. Mutant mice also displayed severe mammary gland development during pregnancy. Here, we seek to understand and unpack the physiological significance of AF-1 in PR activity in mice.
DOI: 10.32657/10356/162450
Schools: School of Biological Sciences 
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: open
Fulltext Availability: With Fulltext
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