Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162493
Title: Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window
Authors: Wu, Xiang
Jiang, Yuyan
Rommelfanger, Nicholas J.
Yang, Fan
Zhou, Qi
Yin, Rongkang
Liu, Junlang
Cai, Sa
Ren, Wei
Shin, Andrew
Ong, Kyrstyn S.
Pu, Kanyi
Hong, Guosong
Keywords: Engineering::Bioengineering
Science::Chemistry::Biochemistry
Issue Date: 2022
Source: Wu, X., Jiang, Y., Rommelfanger, N. J., Yang, F., Zhou, Q., Yin, R., Liu, J., Cai, S., Ren, W., Shin, A., Ong, K. S., Pu, K. & Hong, G. (2022). Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window. Nature Biomedical Engineering, 6(6), 754-770. https://dx.doi.org/10.1038/s41551-022-00862-w
Project: M4081627
MOE2016-T2-1-098
Journal: Nature Biomedical Engineering
Abstract: Neural circuitry is typically modulated via invasive brain implants and tethered optical fibres in restrained animals. Here we show that wide-field illumination in the second near-infrared spectral window (NIR-II) enables implant-and-tether-free deep-brain stimulation in freely behaving mice with stereotactically injected macromolecular photothermal transducers activating neurons ectopically expressing the temperature-sensitive transient receptor potential cation channel subfamily V member 1 (TRPV1). The macromolecular transducers, ~40 nm in size and consisting of a semiconducting polymer core and an amphiphilic polymer shell, have a photothermal conversion efficiency of 71% at 1,064 nm, the wavelength at which light attenuation by brain tissue is minimized (within the 400-1,800 nm spectral window). TRPV1-expressing neurons in the hippocampus, motor cortex and ventral tegmental area of mice can be activated with minimal thermal damage on wide-field NIR-II illumination from a light source placed at distances higher than 50 cm above the animal's head and at an incident power density of 10 mW mm-2. Deep-brain stimulation via wide-field NIR-II illumination may open up opportunities for social behavioural studies in small animals.
URI: https://hdl.handle.net/10356/162493
ISSN: 2157-846X
DOI: 10.1038/s41551-022-00862-w
Rights: © 2022 The Author(s), under exclusive licence to Springer Nature Limited.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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