Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162514
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dc.contributor.authorSung, Joseph Jao Yiuen_US
dc.contributor.authorMoreea, Sullemanen_US
dc.contributor.authorDhaliwal, Harinderen_US
dc.contributor.authorMoffatt, Dana C.en_US
dc.contributor.authorRagunath, Krishen_US
dc.contributor.authorPonich, Terryen_US
dc.contributor.authorBarkun, Alan N.en_US
dc.contributor.authorKuipers, Ernst J.en_US
dc.contributor.authorBailey, Roberten_US
dc.contributor.authorDonnellan, Fergalen_US
dc.contributor.authorWagner, Daviden_US
dc.contributor.authorSanborn, Keithen_US
dc.contributor.authorLau, Jamesen_US
dc.date.accessioned2022-10-26T05:25:45Z-
dc.date.available2022-10-26T05:25:45Z-
dc.date.issued2022-
dc.identifier.citationSung, J. J. Y., Moreea, S., Dhaliwal, H., Moffatt, D. C., Ragunath, K., Ponich, T., Barkun, A. N., Kuipers, E. J., Bailey, R., Donnellan, F., Wagner, D., Sanborn, K. & Lau, J. (2022). Use of topical mineral powder as monotherapy for treatment of active peptic ulcer bleeding. Gastrointestinal Endoscopy, 96(1), 28-35. https://dx.doi.org/10.1016/j.gie.2022.01.020en_US
dc.identifier.issn0016-5107en_US
dc.identifier.urihttps://hdl.handle.net/10356/162514-
dc.description.abstractBackground and Aims: The aim of this study was to evaluate the safety and effectiveness of Hemospray (Cook Medical, Winston-Salem, NC, USA), a hemostatic powder, as monotherapy for active peptic ulcer bleeding. Methods: In this prospective, multicenter, single-arm study, patients with Forrest Ia or Ib peptic ulcers underwent endoscopic application of Hemospray as treatment of first intent. Effectiveness endpoints were successful hemostasis at the end of the index endoscopy, recurrent bleeding within 72 hours and from 72 hours to 30 days, adverse events requiring reintervention or resulting in morbidity or mortality, and 30-day mortality. Results: Hemospray was successfully administered in 98.5% of patients (66/67). Hemostasis was achieved at the index endoscopy in 90.9% of patients (60/66) with Hemospray alone and in an additional 4 patients treated with additional modalities, yielding an overall hemostasis rate of 97.0% (64/66). Rebleeding occurred in 13.3% of patients (8/60), 5 within 72 hours and 3 between 72 hours and 30 days. Two cases of perforation and 2 patient deaths occurred during the study, but none of these cases or any other adverse events were attributed to the use of Hemospray. The rate of early rebleeding was significantly higher in patients with Forrest Ia ulcers compared with patients with Forrest Ib ulcers. Higher rates of early bleeding in patients with Forrest Ia ulcers is consistent with results from studies where Hemospray was used as rescue after failure of conventional methods. Conclusions: Hemospray is an effective initial treatment for patients with active peptic ulcer bleeding, but care should be taken to monitor for recurrent bleeding. (Clinical trial registration number: NCT01306864.) (Gastrointest Endosc 2022;96:28-35.)en_US
dc.language.isoenen_US
dc.relation.ispartofGastrointestinal Endoscopyen_US
dc.rights© 2022 by the American Society for Gastrointestinal Endoscopy. Published by Elsevier, Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectScience::Medicineen_US
dc.titleUse of topical mineral powder as monotherapy for treatment of active peptic ulcer bleedingen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1016/j.gie.2022.01.020-
dc.description.versionPublished versionen_US
dc.identifier.pmid35124074-
dc.identifier.scopus2-s2.0-85127368778-
dc.identifier.issue1en_US
dc.identifier.volume96en_US
dc.identifier.spage28en_US
dc.identifier.epage35en_US
dc.subject.keywordsEpinephrineen_US
dc.subject.keywordsHemosprayen_US
dc.description.acknowledgementThe following authors disclosed financial relationships: J. J. Y. Sung: Editor-in-Chief of the Journal of Gastroenterology and Hepatology. K. Ragunath: Educational and research grants from Cook Medical; associate editor for Digestive Endoscopy Journal. D. Wagner: Employee of Cook Medical. K. Sanborn: Employee of Cook Research Incorporated and Cook Group Company. All other authors disclosed no financial relationships. Research support for this study was provided by Cook Medical.en_US
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