Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162584
Title: Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research
Authors: Rao, Shripada
Esvaran, Meera
Chen, Liwei
Kok, Chooi
Keil, Anthony D.
Gollow, Ian
Simmer, Karen
Wemheuer, Bernd
Conway, Patricia
Patole, Sanjay
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Rao, S., Esvaran, M., Chen, L., Kok, C., Keil, A. D., Gollow, I., Simmer, K., Wemheuer, B., Conway, P. & Patole, S. (2022). Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research. Pediatric Research, 1-7. https://dx.doi.org/10.1038/s41390-022-02087-8
Journal: Pediatric Research
Abstract: Our pilot RCT found that probiotic supplementation with the three-strain bifidobacterial product (B. breve M-16V, B. longum subsp. infantis M-63 and B. longum subsp. longum BB536) attenuates gut dysbiosis, increases stool short-chain fatty acid (SCFA) levels and improves the growth of head circumference in neonates with congenital gastrointestinal surgical conditions (CGISC). In this article, we have provided guidelines for designing future multicentre RCTs based on the experience gained from our pilot RCT. The recommendations include advice about sample size, potential confounders, outcomes of interest, probiotic strain selection, storage, dose, duration and microbial quality assurance, collection of stool samples, storage and analysis and reporting. Following these guidelines will increase the validity of future RCTs in this area and hence confidence in their results. IMPACT: Probiotic supplementation attenuates gut dysbiosis, increases stool short-chain fatty acid (SCFA) levels and improves the growth of head circumference in neonates with congenital gastrointestinal surgical conditions. The current review provides evidence-based guidelines to conduct adequately powered RCTs in this field.
URI: https://hdl.handle.net/10356/162584
ISSN: 0031-3998
DOI: 10.1038/s41390-022-02087-8
Rights: © Crown 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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