Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162599
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dc.contributor.authorWu, Fuqingen_US
dc.contributor.authorLee, Wei Linen_US
dc.contributor.authorChen, Hongjieen_US
dc.contributor.authorGu, Xiaoqiongen_US
dc.contributor.authorChandra, Franciscusen_US
dc.contributor.authorArmas, Federicaen_US
dc.contributor.authorXiao, Amyen_US
dc.contributor.authorLeifels, Matsen_US
dc.contributor.authorRhode, Steven F.en_US
dc.contributor.authorWuertz, Stefanen_US
dc.contributor.authorThompson, Janelleen_US
dc.contributor.authorAlm, Eric J.en_US
dc.date.accessioned2022-11-01T01:08:02Z-
dc.date.available2022-11-01T01:08:02Z-
dc.date.issued2022-
dc.identifier.citationWu, F., Lee, W. L., Chen, H., Gu, X., Chandra, F., Armas, F., Xiao, A., Leifels, M., Rhode, S. F., Wuertz, S., Thompson, J. & Alm, E. J. (2022). Making waves: wastewater surveillance of SARS-CoV-2 in an endemic future. Water Research, 219, 118535-. https://dx.doi.org/10.1016/j.watres.2022.118535en_US
dc.identifier.issn0043-1354en_US
dc.identifier.urihttps://hdl.handle.net/10356/162599-
dc.description.abstractWastewater-based surveillance (WBS) has been widely used as a public health tool to monitor the emergence and spread of SARS-CoV-2 infections in populations during the COVID-19 pandemic. Coincident with the global vaccination efforts, the world is also enduring new waves of SARS-CoV-2 variants. Reinfections and vaccine breakthroughs suggest an endemic future where SARS-CoV-2 continues to persist in the general population. In this treatise, we aim to explore the future roles of wastewater surveillance. Practically, WBS serves as a relatively affordable and non-invasive tool for mass surveillance of SARS-CoV-2 infection while minimizing privacy concerns, attributes that make it extremely suited for its long-term usage. In an endemic future, the utility of WBS will include 1) monitoring the trend of viral loads of targets in wastewater for quantitative estimate of changes in disease incidence; 2) sampling upstream for pinpointing infections in neighborhoods and at the building level; 3) integrating wastewater and clinical surveillance for cost-efficient population surveillance; and 4) genome sequencing wastewater samples to track circulating and emerging variants in the population. We further discuss the challenges and future developments of WBS to reduce inconsistencies in wastewater data worldwide, improve its epidemiological inference, and advance viral tracking and discovery as a preparation for the next viral pandemic.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationNRF2019-THE001-0003aen_US
dc.relation.ispartofWater Researchen_US
dc.rights© 2022 Published by Elsevier Ltd. All rights reserved.en_US
dc.subjectEngineering::Environmental engineeringen_US
dc.titleMaking waves: wastewater surveillance of SARS-CoV-2 in an endemic futureen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Civil and Environmental Engineeringen_US
dc.contributor.schoolAsian School of the Environmenten_US
dc.contributor.organizationCampus for Research Excellence and Technological Enterprise (CREATE)en_US
dc.contributor.researchSingapore Centre for Environmental Life Sciences and Engineering (SCELSE)en_US
dc.identifier.doi10.1016/j.watres.2022.118535-
dc.identifier.pmid35605390-
dc.identifier.scopus2-s2.0-85130847224-
dc.identifier.volume219en_US
dc.identifier.spage118535en_US
dc.subject.keywordsWastewater Surveillanceen_US
dc.subject.keywordsSARS-CoV-2en_US
dc.description.acknowledgementThis work was supported by the MIT Center for Microbiome Informatics and Therapeutics, funding from the Massachusetts Consortium on Pathogen Readiness (MassCPR) and China Evergrande Group (EJA), the National Research Foundation, Prime Minister’s Office, Singapore, under its Campus for Research Excellence and Technological Enterprise (CREATE) program funding to the Singapore-MIT Alliance for Research and Technology (SMART) Antimicrobial Resistance Interdisciplinary Research Group (AMR IRG), the Intra-CREATE Thematic Grant (Cities) grant NRF2019-THE001–0003a to JT and EJA and funding from the Singapore Ministry of Education and National Research Foundation through an RCE award to Singapore centre for Environmental Life Sciences Engineering (SCELSE) to SW and JT. FW is supported by the Faculty Startup funding from the Center of Infectious Diseases at UTHealth, the UT system Rising STARs award, and the Texas Epidemic Public Health Institute (TEPHI), which is housed within and supported administratively by The University of Texas Health Science Center at Houston (UTHealth).en_US
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