Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162618
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dc.contributor.authorTröster, Philipen_US
dc.contributor.authorBerggren, Per-Olofen_US
dc.date.accessioned2022-11-01T04:40:58Z-
dc.date.available2022-11-01T04:40:58Z-
dc.date.issued2022-
dc.identifier.citationTröster, P. & Berggren, P. (2022). Intravital Ca²⁺ imaging of pancreatic β cell function after bariatric surgery. Cell Calcium, 104, 102566-. https://dx.doi.org/10.1016/j.ceca.2022.102566en_US
dc.identifier.issn0143-4160en_US
dc.identifier.urihttps://hdl.handle.net/10356/162618-
dc.description.abstractBariatric surgery has long become an appropriate and common treatment for patients with severe obesity and many related conditions such as type 2 diabetes. However, the exact mechanism leading to improved metabolism shortly after surgery, most notably independent of weight loss, has not yet been fully elucidated. Akalestou's recent publication, "Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice," provides the first detailed insight into the progression of pancreatic islet function after bariatric surgery. By transplanting pancreatic islets equipped with a genetically encoded calcium indicator into the anterior chamber of the eye, improvements in Ca2+ dynamics and a more potent β cell network were observed over an extended time course after the surgical procedure. In the following sections, we will take the opportunity to briefly outline the association between bariatric surgery and diabetes, highlight the issue of anesthesia during intravital Ca2+ imaging, and finally comment on some biological relationships related to β cell function.en_US
dc.language.isoenen_US
dc.relation.ispartofCell Calciumen_US
dc.rights© 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectScience::Medicineen_US
dc.titleIntravital Ca²⁺ imaging of pancreatic β cell function after bariatric surgeryen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1016/j.ceca.2022.102566-
dc.description.versionPublished versionen_US
dc.identifier.pmid35278937-
dc.identifier.scopus2-s2.0-85125935521-
dc.identifier.volume104en_US
dc.identifier.spage102566en_US
dc.subject.keywordsBariatric Surgeryen_US
dc.subject.keywordsDiabetes Mellitusen_US
dc.description.acknowledgementFamiljen Erling-Perssons Stiftelse, Stichting af Jochnick Foundation, Diabetesfonden, European Research Council (ERC) “Advanced Grant” (EYELETS), SSF Stiftelsen f ̈or Strategisk Forskning (Rambidrag MED-X 2018), KI Fonder, Vetenskapsrådet (The Swedisch Research Council), Berth von Kantzows Stiftelse, Novo Nordisk Foundation.en_US
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Appears in Collections:LKCMedicine Journal Articles
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