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Title: Molecular chemiluminescent probes with a very long near-infrared emission wavelength for in vivo imaging
Authors: Huang, Jingsheng
Jiang, Yuyan
Li, Jingchao
Huang, Jiaguo
Pu, Kanyi
Keywords: Science::Chemistry
Issue Date: 2021
Source: Huang, J., Jiang, Y., Li, J., Huang, J. & Pu, K. (2021). Molecular chemiluminescent probes with a very long near-infrared emission wavelength for in vivo imaging. Angewandte Chemie International Edition, 60(8), 3999-4003.
Project: M4081627
Journal: Angewandte Chemie International Edition 
Abstract: Chemiluminescence imaging is imperative for diagnostics and imaging due to its intrinsically high sensitivity. To improve in vivo detection of biomarkers, chemiluminophores that simultaneously possess near-infrared (NIR) emission and modular structures amenable to construction of activatable probes are highly desired; however, these are rare. Herein, we report two chemiluminophores with record long NIR emission (>750 nm) via integration of dicyanomethylene-4H-benzothiopyran or dicyanomethylene-4H-benzoselenopyran with dioxetane unit. Caging of the chemiluminophores with different cleavable moieties produces NIR chemiluminescence probes (NCPs) that only produce signals upon reaction with reactive oxygen species or enzymes, for example, β-galactosidase, with a tissue-penetration depth of up to 2 cm. Thus, this study provides NIR chemiluminescence molecular scaffolds applicable for in vivo turn-on imaging of versatile biomarkers in deep tissues.
ISSN: 1433-7851
DOI: 10.1002/anie.202013531
Rights: © 2020 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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