Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162771
Title: A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue
Authors: Zheng, Lewen
Zhu, Dan Dan
Wang, Wenjun
Liu, Jiyang
Thng, Steven Tien Guan
Chen, Peng
Keywords: Engineering::Chemical engineering
Issue Date: 2022
Source: Zheng, L., Zhu, D. D., Wang, W., Liu, J., Thng, S. T. G. & Chen, P. (2022). A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue. Sensors and Actuators B: Chemical, 372, 132626-. https://dx.doi.org/10.1016/j.snb.2022.132626
Project: RG110/20
RT02/20
MOE2019-T2-2-004
Journal: Sensors and Actuators B: Chemical
Abstract: Glucose is critical to all organisms. Herein, we developed a wire electrode embedded microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid (ISF) of skin or plant tissues with minimal invasiveness. WEMNP is made of proline treated silk fibroin proteins, which provide good mechanical strength (0.75 N/microneedle) for tissue penetration and desirable bioelectronic interface for fast and high-fidelity detection. WEMNP shows specific and linear response to glucose between 3 and 18 mM for detection in skin ISF with a sensitivity of 21.21 nA/mM and between 30 and 180 mM for detection in plant ISF with a sensitivity of 1.22 nA/mM. Such self-administrable WEMNP could be instrumental to long-term home-based management for chronic diseases and to smart agriculturing.
URI: https://hdl.handle.net/10356/162771
ISSN: 0925-4005
DOI: 10.1016/j.snb.2022.132626
Rights: © 2022 Elsevier B.V. All rights reserved. This paper was published in Sensors and Actuators B: Chemical and is made available with permission of Elsevier B.V.
Fulltext Permission: embargo_20241208
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Journal Articles
LKCMedicine Journal Articles

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