Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/162771
Title: | A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue | Authors: | Zheng, Lewen Zhu, Dan Dan Wang, Wenjun Liu, Jiyang Thng, Steven Tien Guan Chen, Peng |
Keywords: | Engineering::Chemical engineering | Issue Date: | 2022 | Source: | Zheng, L., Zhu, D. D., Wang, W., Liu, J., Thng, S. T. G. & Chen, P. (2022). A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue. Sensors and Actuators B: Chemical, 372, 132626-. https://dx.doi.org/10.1016/j.snb.2022.132626 | Project: | RG110/20 RT02/20 MOE2019-T2-2-004 |
Journal: | Sensors and Actuators B: Chemical | Abstract: | Glucose is critical to all organisms. Herein, we developed a wire electrode embedded microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid (ISF) of skin or plant tissues with minimal invasiveness. WEMNP is made of proline treated silk fibroin proteins, which provide good mechanical strength (0.75 N/microneedle) for tissue penetration and desirable bioelectronic interface for fast and high-fidelity detection. WEMNP shows specific and linear response to glucose between 3 and 18 mM for detection in skin ISF with a sensitivity of 21.21 nA/mM and between 30 and 180 mM for detection in plant ISF with a sensitivity of 1.22 nA/mM. Such self-administrable WEMNP could be instrumental to long-term home-based management for chronic diseases and to smart agriculturing. | URI: | https://hdl.handle.net/10356/162771 | ISSN: | 0925-4005 | DOI: | 10.1016/j.snb.2022.132626 | DOI (Related Dataset): | 10.21979/N9/WYLCBJ | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) School of Chemistry, Chemical Engineering and Biotechnology |
Rights: | © 2022 Elsevier B.V. All rights reserved. This paper was published in Sensors and Actuators B: Chemical and is made available with permission of Elsevier B.V. | Fulltext Permission: | embargo_20241208 | Fulltext Availability: | With Fulltext |
Appears in Collections: | CCEB Journal Articles LKCMedicine Journal Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
A silk microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue.pdf Until 2024-12-08 | 839.05 kB | Adobe PDF | Under embargo until Dec 08, 2024 |
SCOPUSTM
Citations
20
21
Updated on Mar 25, 2024
Web of ScienceTM
Citations
20
10
Updated on Oct 30, 2023
Page view(s)
172
Updated on Mar 27, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.