Please use this identifier to cite or link to this item:
Title: Charge-reversal polymer nano-modulators for photodynamic immunotherapy of cancer
Authors: He, Shasha
Li, Jingchao
Cheng, Penghui
Zeng, Ziling
Zhang, Chi
Duan, Hongwei
Pu, Kanyi
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: He, S., Li, J., Cheng, P., Zeng, Z., Zhang, C., Duan, H. & Pu, K. (2021). Charge-reversal polymer nano-modulators for photodynamic immunotherapy of cancer. Angewandte Chemie International Edition, 60(35), 19355-19363.
Project: 2019-T1-002-045
Journal: Angewandte Chemie International Edition 
Abstract: Nanomedicine can regulate the balance between cytotoxic T lymphocytes (CTLs) and suppressive regulatory T lymphocytes (Tregs), which however has been rarely exploited for cancer immunotherapy. We report a charge-reversal polymer nano-modulator (SPDMC N) activated by tumor microenvironment (TME) for photodynamic immunotherapy of cancer. SPDMC N is constructed by conjugating an immunomodulator (demethylcantharidin, DMC) to the side chains of a photodynamic polymer via an acid-liable linker. The negative charge of SPDMC N ensures its high stability in blood circulation and ideal tumor accumulation; exposure to acidic TME reverses its surface charge to positive, enhancing tumor penetration and locally releasing DMC. Upon near-infrared photoirradiation, SPDMC N generates singlet oxygen to ablate tumors and promote maturation of dendritic cells. Released DMC inhibits protein phosphatase 2 (PP2A) activity and decreases Tregs differentiation. Such combinational action induces a sharp increase in CTL/Treg ratio in TME and effectively inhibits both primary and distant tumors in living mice.
ISSN: 1433-7851
DOI: 10.1002/anie.202106392
Rights: © 2021 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles
SPMS Journal Articles

Citations 10

Updated on Nov 27, 2022

Web of ScienceTM
Citations 10

Updated on Dec 4, 2022

Page view(s)

Updated on Dec 5, 2022

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.