Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162814
Title: Charge-reversal polymer nano-modulators for photodynamic immunotherapy of cancer
Authors: He, Shasha
Li, Jingchao
Cheng, Penghui
Zeng, Ziling
Zhang, Chi
Duan, Hongwei
Pu, Kanyi
Keywords: Engineering::Bioengineering
Science::Chemistry
Issue Date: 2021
Source: He, S., Li, J., Cheng, P., Zeng, Z., Zhang, C., Duan, H. & Pu, K. (2021). Charge-reversal polymer nano-modulators for photodynamic immunotherapy of cancer. Angewandte Chemie International Edition, 60(35), 19355-19363. https://dx.doi.org/10.1002/anie.202106392
Project: 2019-T1-002-045
RG125/19
MOE2018-T2-2-042 
A18A8b0059 
Journal: Angewandte Chemie International Edition 
Abstract: Nanomedicine can regulate the balance between cytotoxic T lymphocytes (CTLs) and suppressive regulatory T lymphocytes (Tregs), which however has been rarely exploited for cancer immunotherapy. We report a charge-reversal polymer nano-modulator (SPDMC N) activated by tumor microenvironment (TME) for photodynamic immunotherapy of cancer. SPDMC N is constructed by conjugating an immunomodulator (demethylcantharidin, DMC) to the side chains of a photodynamic polymer via an acid-liable linker. The negative charge of SPDMC N ensures its high stability in blood circulation and ideal tumor accumulation; exposure to acidic TME reverses its surface charge to positive, enhancing tumor penetration and locally releasing DMC. Upon near-infrared photoirradiation, SPDMC N generates singlet oxygen to ablate tumors and promote maturation of dendritic cells. Released DMC inhibits protein phosphatase 2 (PP2A) activity and decreases Tregs differentiation. Such combinational action induces a sharp increase in CTL/Treg ratio in TME and effectively inhibits both primary and distant tumors in living mice.
URI: https://hdl.handle.net/10356/162814
ISSN: 1433-7851
DOI: 10.1002/anie.202106392
Rights: © 2021 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles
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