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Title: Hemicyanine-based near-infrared activatable probes for imaging and diagnosis of diseases
Authors: Zeng, Ziling
Liew, Si Si
Wei, Xin
Pu, Kanyi
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: Zeng, Z., Liew, S. S., Wei, X. & Pu, K. (2021). Hemicyanine-based near-infrared activatable probes for imaging and diagnosis of diseases. Angewandte Chemie International Edition, 60(51), 26454-26475.
Project: 2019-T1-002-045 
Journal: Angewandte Chemie International Edition 
Abstract: Molecular activatable probes with near-infrared (NIR) fluorescence play a critical role in in vivo imaging of biomarkers for drug screening and disease diagnosis. With structural diversity and high fluorescence quantum yields, hemicyanine dyes have emerged as a versatile scaffold for the construction of activatable optical probes. This Review presents a survey of hemicyanine-based NIR activatable probes (HNAPs) for in vivo imaging and early diagnosis of diseases. The molecular design principles of HNAPs towards activatable optical signaling against various biomarkers are discussed with a focus on their broad applications in the detection of diseases including inflammation, acute organ failure, skin diseases, intestinal diseases, and cancer. This progress not only proves the unique value of HNAPs in preclinical research but also highlights their high translational potential in clinical diagnosis.
ISSN: 1433-7851
DOI: 10.1002/anie.202107877
Rights: © 2021 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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