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Title: Hybrid polymer networks of carbene and thiol ene
Authors: Djordjevic, Ivan
Wicaksono, Gautama
Singh, Juhi
Singh, Manisha
Ellis, Elizabeth G.
Alraddadi, Maher A
Dove, Andrew P.
Steele, Terry W. J.
Keywords: Engineering::Materials::Biomaterials
Science::Chemistry::Organic chemistry::Polymers
Issue Date: 2022
Source: Djordjevic, I., Wicaksono, G., Singh, J., Singh, M., Ellis, E. G., Alraddadi, M. A., Dove, A. P. & Steele, T. W. J. (2022). Hybrid polymer networks of carbene and thiol ene. European Polymer Journal, 178, 111502-.
Project: RT07/20 
H19/01/ a0/0II9 
Journal: European Polymer Journal 
Abstract: Thiol/ene-based resorbable elastomers display tough elongation but lack adhesion to soft tissues. Carbene-based bioadhesives (e.g. CaproGlu) allow soft tissue adhesion, but the covalent crosslinks limit extensibility after photoactivation. Herein thiol/ene resorbable elastomers are combined with a carbene bioadhesive into a 3-component hybrid network by exploiting tunable photoactivation of each macromolecule independently or simultaneously. Dual crosslinking was monitored by photorheometry, where 405 nm initiates formation of a thiol/ene elastomeric network, followed by 365 nm activation of diazirine-grafted polycaprolactone tetrol (CaproGlu). Dynamic shear moduli, gelation point, elongation at break, and lap shear stress of the hybrid polymer network are evaluated with respect to absorbed light energy dose. Surface-exposed unreacted CaproGlu enables adhesion of the hybrid network to various substrates, as well as intermolecular crosslinking within the transparent matrix. The network morphology and functional group conversion is evaluated through scanning electron microscopy and infrared spectroscopy, respectively. For the first time, we demonstrate hybrid thiol/ene/diazirine double sided bioadhesives with tunable dynamic moduli in the range of 10–800 kPa and 160 kPa lap-shear adhesion strength.
ISSN: 0014-3057
DOI: 10.1016/j.eurpolymj.2022.111502
Schools: School of Materials Science and Engineering 
School of Chemical and Biomedical Engineering 
Interdisciplinary Graduate School (IGS) 
Research Centres: NTU Institute for Health Technologies 
Rights: © 2022 Elsevier Ltd. All rights reserved. This paper was published in European Polymer Journal and is made available with permission of Elsevier Ltd.
Fulltext Permission: embargo_20240912
Fulltext Availability: With Fulltext
Appears in Collections:IGS Journal Articles
MSE Journal Articles
SCBE Journal Articles

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I. Djordjevic et al. EPJ_REVISED_UMARKED_Manuscript.pdf
  Until 2024-09-12
Manuscript1.76 MBAdobe PDFUnder embargo until Sep 12, 2024
I. Djordjevic et al. REVISED Supplementary Information.pdf
  Until 2024-09-12
Supplementary Information1.75 MBAdobe PDFUnder embargo until Sep 12, 2024

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